Antibodies to TNF-α:: Too little, too late?

被引:5
作者
Kirschenbaum, L [1 ]
Astiz, M [1 ]
Rackow, EC [1 ]
机构
[1] St Vincent Hosp & Med Ctr, New York, NY 10011 USA
关键词
tumor necrosis factor-alpha; sepsis; cytokines; septic shock;
D O I
10.1097/00003246-199810000-00004
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
引用
收藏
页码:1625 / 1626
页数:2
相关论文
共 11 条
[1]   EFFICACY AND SAFETY OF MONOCLONAL-ANTIBODY TO HUMAN TUMOR-NECROSIS-FACTOR-ALPHA IN PATIENTS WITH SEPSIS SYNDROME - A RANDOMIZED, CONTROLLED, DOUBLE-BLIND, MULTICENTER CLINICAL-TRIAL [J].
ABRAHAM, E ;
WUNDERINK, R ;
SILVERMAN, H ;
PERL, TM ;
NASRAWAY, S ;
LEVY, H ;
BONE, R ;
WENZEL, RP ;
BALK, R ;
ALLRED, R ;
PENNINGTON, JE ;
WHERRY, JC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (12) :934-941
[2]  
Abraham E, 1998, LANCET, V351, P929
[3]   REPEATED ADMINISTRATION OF A F(AB')2 FRAGMENT OF AN ANTITUMOR NECROSIS FACTOR-ALPHA MONOCLONAL-ANTIBODY IN PATIENTS WITH SEVERE SEPSIS - EFFECTS ON THE CARDIOVASCULAR-SYSTEM AND CYTOKINE LEVELS [J].
BOEKSTEGERS, P ;
WEIDENHOFER, S ;
ZELL, R ;
PILZ, G ;
HOLLER, E ;
ERTEL, W ;
KAPSNER, T ;
REDL, H ;
SCHLAG, G ;
KAUL, M ;
KEMPENI, J ;
STENZEL, R ;
WERDAN, K .
SHOCK, 1994, 1 (04) :237-245
[4]   Effect of a chimeric antibody to tumor necrosis factor-α on cytokine and physiologic responses in patients with severe sepsis -: A randomized, clinical trial [J].
Clark, MA ;
Plank, LD ;
Connolly, AB ;
Streat, SJ ;
Hill, AA ;
Gupta, R ;
Monk, DN ;
Shenkin, A ;
Hill, GL .
CRITICAL CARE MEDICINE, 1998, 26 (10) :1650-1659
[5]   CDP571, A HUMANIZED ANTIBODY TO HUMAN TUMOR-NECROSIS-FACTOR-ALPHA - SAFETY, PHARMACOKINETICS, IMMUNE-RESPONSE, AND INFLUENCE OF THE ANTIBODY ON CYTOKINE CONCENTRATIONS IN PATIENTS WITH SEPTIC SHOCK [J].
DHAINAUT, JFA ;
VINCENT, JL ;
RICHARD, C ;
LEJEUNE, P ;
MARTIN, C ;
FIEROBE, L ;
STEPHENS, S ;
NEY, UM ;
SOPWITH, M ;
MERCAT, A ;
EDOUARD, A ;
FRIEDMAN, G ;
MARIN, N ;
SCHLEMMER, B ;
LEPAPE, A ;
NOVAK, C .
CRITICAL CARE MEDICINE, 1995, 23 (09) :1461-1469
[6]   Prevention of Jarisch-Herxheimer reactions by treatment with antibodies against tumor necrosis factor alpha [J].
Fekade, D ;
Knox, K ;
Hussein, K ;
Melka, A ;
Lalloo, DG ;
Coxon, RE ;
Warrell, DA .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (05) :311-315
[7]   INFLUENCE OF AN ANTITUMOR NECROSIS FACTOR MONOCLONAL-ANTIBODY ON CYTOKINE LEVELS IN PATIENTS WITH SEPSIS [J].
FISHER, CJ ;
OPAL, SM ;
DHAINAUT, JF ;
STEPHENS, S ;
ZIMMERMAN, JL ;
NIGHTINGALE, P ;
HARRIS, SJ ;
SCHEIN, RMH ;
PANACEK, EA ;
VINCENT, JL ;
FOULKE, GE ;
WARREN, EL ;
GARRARD, C ;
PARK, G ;
BODMER, MW ;
COHEN, J ;
VANDERLINDEN, C ;
CROSS, AS ;
SADOFF, JC ;
GORECKI, J ;
DUBIN, HG ;
GARNER, C ;
KAYE, W ;
LANORE, JJ ;
MIRA, JP ;
ZIMMERMAN, J ;
DELLINGER, RP ;
TAYLOR, RW ;
DAHL, S ;
SHELLY, M ;
MORTIMER, A ;
EDWARDS, JD ;
KETT, DH ;
QUARTIN, A ;
PENA, MA ;
BAKKER, J ;
ALBERSON, TE ;
WALBY, W ;
RADCLIFFE, J ;
YOUNG, D ;
MCQUILLAM, P ;
BELLINGHAM, G ;
BURMAN, W ;
SADOFF, JS ;
YOUNG, L .
CRITICAL CARE MEDICINE, 1993, 21 (03) :318-327
[8]   NATURAL CYTOKINE ANTAGONISTS AND ENDOGENOUS ANTIENDOTOXIN CORE ANTIBODIES IN SEPSIS SYNDROME [J].
GOLDIE, AS ;
FEARON, KCH ;
ROSS, JA ;
BARCLAY, GR ;
JACKSON, RE ;
GRANT, IS ;
RAMSAY, G ;
BLYTH, AS ;
HOWIE, JC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (02) :172-177
[9]   MODULATION OF ACUTE GRAFT-VERSUS-HOST DISEASE AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION BY TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) RELEASE IN THE COURSE OF PRETRANSPLANT CONDITIONING - ROLE OF CONDITIONING REGIMENS AND PROPHYLACTIC APPLICATION OF A MONOCLONAL-ANTIBODY NEUTRALIZING HUMAN TNF-ALPHA (MAK 195F) [J].
HOLLER, E ;
KOLB, HJ ;
MITTERMULLER, J ;
KAUL, M ;
LEDDEROSE, G ;
DUELL, T ;
SEEBER, B ;
SCHLEUNING, M ;
HINTERMEIERKNABE, R ;
ERTL, B ;
KEMPENI, J ;
WILMANNS, W .
BLOOD, 1995, 86 (03) :890-899
[10]   Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: A multicenter, randomized, placebo-controlled, dose-ranging study [J].
Reinhart, K ;
WiegandLohnert, C ;
Grimminger, F ;
Kaul, M ;
Withington, S ;
Treacher, D ;
Eckart, J ;
Willatts, S ;
Bouza, C ;
Krausch, D ;
Stockenhuber, F ;
Eiselstein, J ;
Daum, L ;
Kempeni, J .
CRITICAL CARE MEDICINE, 1996, 24 (05) :733-742