Effect of Estrogen Receptor β A1730G Polymorphism on ABCA1 Gene Expression Response to Postmenopausal Hormone Replacement Therapy

被引:10
|
作者
Darabi, Maryam [1 ]
Ani, Mohsen [1 ]
Panjehpour, Mojtaba [1 ]
Rabbani, Mohammed [2 ]
Movahedian, Ahmad [1 ,3 ]
Zarean, Elahe [4 ]
机构
[1] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan 8174673461, Iran
[2] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Biotechnol, Esfahan 8174673461, Iran
[3] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Isfahan Pharmaceut Res Ctr, Esfahan 8174673461, Iran
[4] Isfahan Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Esfahan 8174673461, Iran
关键词
BONE-MINERAL DENSITY; ER-ALPHA; ASSOCIATION; APOLIPOPROTEIN; LIPOPROTEIN; METABOLISM; LIPIDS; WOMEN; MICE;
D O I
10.1089/gtmb.2010.0106
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The estrogen receptor beta (ER beta) mediates the action of estrogen on metabolism of lipids and lipoprotein. Therefore, its gene is a promising candidate gene for cardiovascular disease. The aim of the present study was to investigate whether the ER beta A1730G polymorphism modifies the metabolic response to hormone replacement therapy (HRT) in postmenopausal women. The population included 60 normolipidemic postmenopausal women with equal numbers of each A1730G genotype followed during a 90-day experimental period. All subjects received oral estrogen together with a progestin therapy during the HRT. ABCA1 gene expression and serum lipid and lipoprotein concentrations were measured at the beginning and end of the HRT trial. At baseline, ABCA1 gene expression, lipid or lipoprotein concentrations were not significantly different among the ER beta A1730G genotype groups. After HRT, however, subjects with GG genotype had a greater increase in ABCA1 gene expression (p = 0.002) and a trend toward greater increase in apoA-I (p = 0.058) than subjects carrying the A allele. An interaction effect between genotype and HRT effect was observed on ABCA1 gene expression. In conclusion, the positive changes of ABCA1 gene expression and apoA-I were affected by the ER beta A1730G polymorphism in women taking estrogen-progesterone therapy.
引用
收藏
页码:11 / 15
页数:5
相关论文
共 50 条
  • [21] Quantitative assessment of the effect of ABCA1 gene polymorphism on the risk of Alzheimer's disease
    Wang, Xiao-Feng
    Cao, Yuan-Wu
    Feng, Zhen-Zhou
    Fu, Da
    Ma, Yu-Shui
    Zhang, Feng
    Jiang, Xiao-Xing
    Shao, Yun-Chao
    MOLECULAR BIOLOGY REPORTS, 2013, 40 (02) : 779 - 785
  • [22] Atorvastatin and hormone therapy influence expression of ABCA1, APOA1 and SCARB1 in mononuclear cells from hypercholesterolemic postmenopausal women
    Cerda, Alvaro
    Issa, Mustafa H.
    Genvigir, Fabiana D. V.
    Rohde, Cintia B.
    Cavalli, Selma A.
    Bertolami, Marcelo C.
    Faludi, Andre A.
    Hirata, Mario H.
    Hirata, Rosario D. C.
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2013, 138 : 403 - 409
  • [23] +1730 G/A polymorphism of the estrogen receptor β gene (ERβ) may be an important genetic factor predisposing to endometriosis
    Bianco, Bianca
    Maria, Denise
    Mafra, Christofolini Fernanda Abani
    Brandes, Ariel
    Zulli, Karina
    Barbosa, Caio Parente
    ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2009, 88 (12) : 1397 - 1401
  • [24] Analysis of the Influence of Hormone Replacement Therapy on Osteocalcin Gene Expression in Postmenopausal Women
    Rahnama, Mansur
    Jastrzebska-Jamrogiewicz, Izabela
    Jamrogiewicz, Rafal
    Trybek, Grzegorz
    BIOMED RESEARCH INTERNATIONAL, 2015, 2015
  • [25] Effect of raloxifene, estrogen, and hormone replacement therapy on serum homocysteine levels in postmenopausal women
    Christodoulakos, G
    Lambrinoudaki, I
    Panoulis, C
    Rizos, D
    Coutoukos, J
    Creatsas, G
    FERTILITY AND STERILITY, 2003, 79 (02) : 455 - 456
  • [26] Effect of postmenopausal hormone therapy on cognitive function: The heart and estrogen/progestin replacement study
    Grady, D
    Yaffe, K
    Kristof, M
    Lin, F
    Richards, C
    Barrett-Connor, E
    AMERICAN JOURNAL OF MEDICINE, 2002, 113 (07): : 543 - 548
  • [27] A beneficial effect of estrogen on working memory in postmenopausal women taking hormone replacement therapy
    Duff, SJ
    Hampson, E
    HORMONES AND BEHAVIOR, 2000, 38 (04) : 262 - 276
  • [28] Association of vitamin D and estrogen receptor gene polymorphism with the effects of longterm hormone replacement therapy on bone mineral density
    Takumi Kurabayashi
    Hiroshi Matsushita
    Masatoshi Tomita
    Nozomi Kato
    Mariko Kikuchi
    Hiroshi Nagata
    Akira Honda
    Tetsuro Yahata
    Kenichi Tanaka
    Journal of Bone and Mineral Metabolism, 2004, 22 : 241 - 247
  • [29] Association of vitamin D and estrogen receptor gene polymorphism with the effects of longterm hormone replacement therapy on bone mineral density
    Kurabayashi, T
    Matsushita, H
    Tomita, M
    Kato, N
    Kikuchi, M
    Nagata, H
    Honda, A
    Yahata, T
    Tanaka, K
    JOURNAL OF BONE AND MINERAL METABOLISM, 2004, 22 (03) : 241 - 247
  • [30] The protective effect of hormone-replacement therapy on fracture risk is modulated by estrogen receptor α genotype in early postmenopausal women
    Salmén, T
    Heikkinen, AM
    Mahonen, A
    Kröger, H
    Komulainen, M
    Saarikoski, S
    Honkanen, R
    Mäenpää, PH
    JOURNAL OF BONE AND MINERAL RESEARCH, 2000, 15 (12) : 2479 - 2486