Effect of Estrogen Receptor β A1730G Polymorphism on ABCA1 Gene Expression Response to Postmenopausal Hormone Replacement Therapy

被引:10
|
作者
Darabi, Maryam [1 ]
Ani, Mohsen [1 ]
Panjehpour, Mojtaba [1 ]
Rabbani, Mohammed [2 ]
Movahedian, Ahmad [1 ,3 ]
Zarean, Elahe [4 ]
机构
[1] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan 8174673461, Iran
[2] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Biotechnol, Esfahan 8174673461, Iran
[3] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Isfahan Pharmaceut Res Ctr, Esfahan 8174673461, Iran
[4] Isfahan Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Esfahan 8174673461, Iran
关键词
BONE-MINERAL DENSITY; ER-ALPHA; ASSOCIATION; APOLIPOPROTEIN; LIPOPROTEIN; METABOLISM; LIPIDS; WOMEN; MICE;
D O I
10.1089/gtmb.2010.0106
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The estrogen receptor beta (ER beta) mediates the action of estrogen on metabolism of lipids and lipoprotein. Therefore, its gene is a promising candidate gene for cardiovascular disease. The aim of the present study was to investigate whether the ER beta A1730G polymorphism modifies the metabolic response to hormone replacement therapy (HRT) in postmenopausal women. The population included 60 normolipidemic postmenopausal women with equal numbers of each A1730G genotype followed during a 90-day experimental period. All subjects received oral estrogen together with a progestin therapy during the HRT. ABCA1 gene expression and serum lipid and lipoprotein concentrations were measured at the beginning and end of the HRT trial. At baseline, ABCA1 gene expression, lipid or lipoprotein concentrations were not significantly different among the ER beta A1730G genotype groups. After HRT, however, subjects with GG genotype had a greater increase in ABCA1 gene expression (p = 0.002) and a trend toward greater increase in apoA-I (p = 0.058) than subjects carrying the A allele. An interaction effect between genotype and HRT effect was observed on ABCA1 gene expression. In conclusion, the positive changes of ABCA1 gene expression and apoA-I were affected by the ER beta A1730G polymorphism in women taking estrogen-progesterone therapy.
引用
收藏
页码:11 / 15
页数:5
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