The UCSC Genome Browser database: update 2011

被引:764
作者
Fujita, Pauline A. [1 ]
Rhead, Brooke [1 ]
Zweig, Ann S. [1 ]
Hinrichs, Angie S. [1 ]
Karolchik, Donna [1 ]
Cline, Melissa S. [1 ]
Goldman, Mary [1 ]
Barber, Galt P. [1 ]
Clawson, Hiram [1 ]
Coelho, Antonio [1 ]
Diekhans, Mark [1 ]
Dreszer, Timothy R. [1 ]
Giardine, Belinda M. [2 ]
Harte, Rachel A. [1 ]
Hillman-Jackson, Jennifer [1 ]
Hsu, Fan [1 ]
Kirkup, Vanessa [1 ]
Kuhn, Robert M. [1 ]
Learned, Katrina [1 ]
Li, Chin H. [1 ]
Meyer, Laurence R. [1 ]
Pohl, Andy [1 ,3 ]
Raney, Brian J. [1 ]
Rosenbloom, Kate R. [1 ]
Smith, Kayla E. [1 ]
Haussler, David [1 ,4 ]
Kent, W. James [1 ]
机构
[1] Univ Calif Santa Cruz, Sch Engn, Ctr Biomol Sci & Engn, Santa Cruz, CA 95064 USA
[2] Penn State Univ, Huck Inst Life Sci, Ctr Comparat Genom & Bioinformat, University Pk, PA 16802 USA
[3] Ctr Genom Regulat CRG, Barcelona, Spain
[4] Univ Calif Santa Cruz, Howard Hughes Med Inst, Santa Cruz, CA 95064 USA
关键词
SEQUENCE;
D O I
10.1093/nar/gkq963
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The University of California, Santa Cruz Genome Browser (http://genome.ucsc.edu) offers online access to a database of genomic sequence and annotation data for a wide variety of organisms. The Browser also has many tools for visualizing, comparing and analyzing both publicly available and user-generated genomic data sets, aligning sequences and uploading user data. Among the features released this year are a gene search tool and annotation track drag-reorder functionality as well as support for BAM and BigWig/BigBed file formats. New display enhancements include overlay of multiple wiggle tracks through use of transparent coloring, options for displaying transformed wiggle data, a 'mean+whiskers' windowing function for display of wiggle data at high zoom levels, and more color schemes for microarray data. New data highlights include seven new genome assemblies, a Neandertal genome data portal, phenotype and disease association data, a human RNA editing track, and a zebrafish Conservation track. We also describe updates to existing tracks.
引用
收藏
页码:D876 / D882
页数:7
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