Microglia dynamics and function in the CNS

被引:91
|
作者
Parkhurst, Christopher N. [1 ]
Gan, Wen-Biao [1 ]
机构
[1] NYU, Sch Med, Mol Neurobiol Program, Skirball Inst,Dept Physiol & Neurosci, New York, NY 10016 USA
基金
美国国家卫生研究院;
关键词
PERIPHERAL-NERVE INJURY; TOLL-LIKE RECEPTORS; SPINAL-CORD-INJURY; IN-VIVO; NEUROPATHIC PAIN; ACTIVATED MICROGLIA; UP-REGULATION; MOUSE-BRAIN; ATP; PROLIFERATION;
D O I
10.1016/j.conb.2010.07.002
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Microglial cells constitute the resident immune cell population of the mammalian central nervous system. One striking feature of these cells is their highly dynamic nature under both normal and pathological brain conditions. The highly branched processes of resting microglia display a constitutive mobility and undergo rapid directional movement towards sites of acute tissue disruption. Microglia can be converted by a large number of different stimuli to a chronically activated state by signaling through both purinergic and Toll-like receptor systems, among others. Recent work has uncovered some of the mechanisms underlying microglia dynamics and shed new light into the functional significance of this enigmatic member of the glial cell family.
引用
收藏
页码:595 / 600
页数:6
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