机构:
NYU, Sch Med, Mol Neurobiol Program, Skirball Inst,Dept Physiol & Neurosci, New York, NY 10016 USANYU, Sch Med, Mol Neurobiol Program, Skirball Inst,Dept Physiol & Neurosci, New York, NY 10016 USA
Parkhurst, Christopher N.
[1
]
Gan, Wen-Biao
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机构:
NYU, Sch Med, Mol Neurobiol Program, Skirball Inst,Dept Physiol & Neurosci, New York, NY 10016 USANYU, Sch Med, Mol Neurobiol Program, Skirball Inst,Dept Physiol & Neurosci, New York, NY 10016 USA
Gan, Wen-Biao
[1
]
机构:
[1] NYU, Sch Med, Mol Neurobiol Program, Skirball Inst,Dept Physiol & Neurosci, New York, NY 10016 USA
Microglial cells constitute the resident immune cell population of the mammalian central nervous system. One striking feature of these cells is their highly dynamic nature under both normal and pathological brain conditions. The highly branched processes of resting microglia display a constitutive mobility and undergo rapid directional movement towards sites of acute tissue disruption. Microglia can be converted by a large number of different stimuli to a chronically activated state by signaling through both purinergic and Toll-like receptor systems, among others. Recent work has uncovered some of the mechanisms underlying microglia dynamics and shed new light into the functional significance of this enigmatic member of the glial cell family.
机构:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA
San Francisco VA Med Ctr, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA
Kawabori, Masahito
Yenari, Midori A.
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机构:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA
San Francisco VA Med Ctr, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA