Profile of Acute Infectious Markers in Sporadic Hepatitis E

被引:109
作者
Huang, Shoujie [1 ,2 ]
Zhang, Xuefeng [3 ]
Jiang, Hanmin [4 ]
Yan, Qiang [1 ]
Ai, Xing [3 ]
Wang, Yijun [4 ]
Cai, Jiaping [4 ]
Jiang, Lang [1 ]
Wu, Ting [1 ]
Wang, Zhongze [4 ]
Guan, Li [1 ]
Shih, J. Wai Kuo [1 ]
Ng, Mun-Hon [1 ]
Zhu, Fengcai [3 ]
Zhang, Jun [1 ]
Xia, Ningshao [1 ]
机构
[1] Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, Xiamen, Peoples R China
[2] Xiamen Univ, Coll Med, Dept Prevent Med, Xiamen, Peoples R China
[3] Jiangsu Prov Ctr Dis Control & Prevent, Nanjing, Peoples R China
[4] Dongtai Ctr Dis Control & Prevent, Dongtai, Peoples R China
来源
PLOS ONE | 2010年 / 5卷 / 10期
关键词
E VIRUS-INFECTION; IMMUNOGLOBULIN-M; UNITED-STATES; OUTBREAK; ASSAYS; DISEASE; ANTIBODIES; DIAGNOSIS; ZOONOSIS; NAMIBIA;
D O I
10.1371/journal.pone.0013560
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Laboratory diagnosis of acute infection of hepatitis E virus (HEV) is commonly based on the detection of HEV RNA, IgM and/or rising IgG levels. However, the profile of these markers when the patients present have not been well determined. To clarify the extent of misdiagnosed sporadic hepatitis E in the initial laboratory detection, serial sera of 271 sporadic acute hepatitis cases were collected, detected and the dynamics of each acute marker during the illness course were analyzed. 91 confirmed cases of hepatitis E were identified based on the presentation of HEV RNA, IgM or at least 4 fold rising of IgG levels. 21 (23.1%) hepatitis E cases were false negative for the viral RNA and 40 (44.0%) for rising IgG, because occurrence of these markers were confined to acute phase of infection and viremia had already subsided and antibody level peaked when these patients presented. IgM was detected in 82 (90.1%) cases. It is the most prevalent of the three markers, because the antibody persisted until early convalescence. Nine cases negative for IgM were positive for rising IgG and one was also positive for the viral RNA; all of these nine cases showed high avid IgG in their acute phase sera, which indicated reinfection. In summary, it is not practicable to determine the true occurrence of sporadic hepatitis E. Nevertheless, it could be closely approximated by approach using a combination of all three acute markers.
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页数:7
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