Identification and characterization of two novel human papillomavi ruses (HPVs) by overlapping PICR: HPV102 and HPV106

被引：18
作者：
Chen, Zigui
Schiffman, Mark
Herrero, Rolando
Burk, Robert D. [1 ]
机构：
[1] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10467 USA
[2] US Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, NCI, NIH, Bethesda, MD USA
[3] Costa Rican Fdn Hlth Sci, San Jose, Costa Rica
[4] Albert Einstein Coll Med, Dept Pediat, Dept Epidemiol & Populat Hlth, Dept Obstet Gynecol & Womans Hlth, Bronx, NY 10467 USA
[5] Albert Einstein Coll Med, Albert Einstein Canc Ctr, Bronx, NY 10467 USA
来源：
JOURNAL OF GENERAL VIROLOGY | 2007年 / 88卷
关键词：
D O I：
10.1099/vir.0.83178-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Complete genomes of HPV102 (8078 bp) and HPV106 (8035 bp) were PCR amplified and cloned from cervicovaginal cells of a 49-year-old Hispanic female with reactive changes on her Pap test and a 42-year-old Hispanic female with a Pap test diagnosis of atypical squamous cells of unknown significance (ASCUS), respectively. The nucleotide sequence similarity of the complete L1 open reading frame (ORF) determined that HPV102 and HPV1 06 are most closely related to HPV83 (84.1 % identity) and HPV90 (83.5 % identity), respectively, placing them in the genital HPV groups, papillomaviruses species alpha 3 and alpha 15. HPV1 02 and HPV1 06 contain five early genes (E6, E7, E1, E2, and E4) and two late genes (L2 and L1), and both lack an E5 ORF. On the basis of phylogenetic analyses and available clinical information, these two novel HPV types expand the heterogeneity of HPVs detected in the lower genital tract.
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收藏
页码：2952 / 2955
页数：4
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