FGF Family: From Drug Development to Clinical Application

被引：134
作者：
Hui, Qi [1 ]
Jin, Zi [1 ]
Li, Xiaokun [1 ,2 ]
Liu, Changxiao [1 ,3 ]
Wang, Xiaojie [1 ,2 ]
机构：
[1] Wenzhou Med Univ, Sch Pharm, Chashan Univ Pk, Wenzhou 325035, Peoples R China
[2] Wenzhou Med Univ, Key Lab Biotechnol Pharmaceut Engn, Chashan Univ Pk, Wenzhou 325035, Peoples R China
[3] Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, 308 Anshan West Rd, Tianjin 300193, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 07期
基金：
中国国家自然科学基金;
关键词：
fibroblast growth factor; wound healing; metabolic regulation; fibroblast growth factor receptor inhibitor; drug development; clinical application; FIBROBLAST-GROWTH-FACTOR; X-LINKED HYPOPHOSPHATEMIA; ANTI-FGF23 ANTIBODY KRN23; FACTOR RECEPTORS FGFRS; CHRONIC KIDNEY-DISEASE; BREAST-CANCER; GENE AMPLIFICATION; RANDOMIZED-TRIAL; GASTRIC-CANCER; CARDIOVASCULAR-DISEASE;
D O I：
10.3390/ijms19071875
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fibroblast growth factor (FGF) belongs to a large family of growth factors. FGFs use paracrine or endocrine signaling to mediate a myriad of biological and pathophysiological process, including angiogenesis, wound healing, embryonic development, and metabolism regulation. FGF drugs for the treatment of burn and ulcer wounds are now available. The recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in maintaining homeostasis of bile acid, glucose, and phosphate further extended the activity profile of this family. Here, the applications of recombinant FGFs for the treatment of wounds, diabetes, hypophosphatemia, the development of FGF receptor inhibitors as anti-neoplastic drugs, and the achievements of basic research and applications of FGFs in China are reviewed.
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页数：15
相关论文
共 107 条
[1]   FGFR2 in gastric cancer: protein overexpression predicts gene amplification and high H-index predicts poor survival [J].
Ahn, Soomin ;
Lee, Jeeyun ;
Hong, Mineui ;
Kim, Seung Tae ;
Park, Se Hoon ;
Choi, Min Gew ;
Lee, Jun-Ho ;
Sohn, Tae Sung ;
Bae, Jae Moon ;
Kim, Sung ;
Jung, Sin-Ho ;
Kang, Won Ki ;
Kim, Kyoung-Mee .
MODERN PATHOLOGY, 2016, 29 (09) :1095-1103
[2]   Endothelial Rictor is crucial for midgestational development and sustained and extensive FGF2-induced neovascularization in the adult [J].
Aimi, Fabio ;
Georgiopoulou, Stavroula ;
Kalus, Ina ;
Lehner, Fabienne ;
Hegglin, Alica ;
Limani, Perparim ;
de Lima, Vinicius Gomes ;
Ruegg, Markus A. ;
Hall, Michael N. ;
Lindenblatt, Nicole ;
Haas, Elvira ;
Battegay, Edouard J. ;
Humar, Rok .
SCIENTIFIC REPORTS, 2015, 5
[3]   Brivanib, a Dual FGF/VEGF Inhibitor, Is Active Both First and Second Line against Mouse Pancreatic Neuroendocrine Tumors Developing Adaptive/Evasive Resistance to VEGF Inhibition [J].
Allen, Elizabeth ;
Walters, Ian B. ;
Hanahan, Douglas .
CLINICAL CANCER RESEARCH, 2011, 17 (16) :5299-5310
[4]   PITUITARY EXTRACTS AND STEROID-HORMONES IN CONTROL 3T3-CELL GROWTH [J].
ARMELIN, HA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (09) :2702-2706
[5]   Phosphate and FGF-23 homeostasis after kidney transplantation [J].
Baia, Leandro C. ;
Heilberg, Ita Pfeferman ;
Navis, Gerjan ;
de Borst, Martin H. .
NATURE REVIEWS NEPHROLOGY, 2015, 11 (11) :656-666
[6]   Clinical application of growth factors and cytokines in wound healing [J].
Barrientos, Stephan ;
Brem, Harold ;
Stojadinovic, Olivera ;
Tomic-Canic, Marjana .
WOUND REPAIR AND REGENERATION, 2014, 22 (05) :569-578
[7]   Molecular Mechanisms of Fibroblast Growth Factor Signaling in Physiology and Pathology [J].
Belov, Artur A. ;
Mohammadi, Moosa .
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2013, 5 (06)
[8]  
Bernuy Jeanette, 2015, Rev. perú. med. exp. salud publica, V32, P326
[9]   Interactions of signaling proteins, growth factors and other proteins with heparan sulfate: mechanisms and mysteries [J].
Billings, Paul C. ;
Pacifici, Maurizio .
CONNECTIVE TISSUE RESEARCH, 2015, 56 (04) :272-280
[10]   Randomized, multicenter, double-blind, and placebo-controlled trial using topical recombinant human acidic fibroblast growth factor for deep partial-thickness burns and skin graft donor site [J].
Bing, Ma ;
Da-Sheng, Cheng ;
Zhao-Fan, Xia ;
Dao-Feng, Ben ;
Wei, Lu ;
Zhi-Fang, Cao ;
Qiang, Wang ;
Jia, He ;
Jia-Ke, Chai ;
Chuan-An, Shen ;
Yong-Hua, Sun ;
Guo-An, Zhang ;
Xiao-Hua, Hu .
WOUND REPAIR AND REGENERATION, 2007, 15 (06) :795-799
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