Visible-light-promoted radical cross-coupling of para-quinone methides with N-substituted anilines: an efficient approach to 2,2-diarylethylamines

被引：23

作者：

Wu, Qiao-Lei ^{[1
]}

Guo, Jing ^{[1
]}

Huang, Gong-Bin ^{[1
]}

Chan, Albert S. C. ^{[1
]}

Weng, Jiang ^{[1
]}

Lu, Gui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab Chiral Mol & Drug Discover, Guangzhou 510006, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ALPHA-AMINOALKYL RADICALS; ASYMMETRIC 1,6-CONJUGATE ADDITION; ELECTRON-DEFICIENT ALKENES; ENANTIOSELECTIVE SYNTHESIS; ARYLBORONIC ACIDS; PHOTOREDOX; ACCESS; DEPROTONATION; NITROALKENES; GENERATION;

D O I：

10.1039/c9ob02600b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient protocol to access 2,2-diarylethylamines via visible-light-promoted radical reactions of para-quinone methides (p-QMs) with N-alkyl anilines has been disclosed. These reactions feature metal-free, redox-neutral, and mild reaction conditions with wide functional group compatibility.

引用

页码：860 / 864

页数：5

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