Microbiome Metabolites and Thyroid Dysfunction

被引：42

作者：

Bargiel, Piotr ^{[1
]}

Szczuko, Malgorzata ^{[2
]}

Stachowska, Laura ^{[2
]}

Prowans, Piotr ^{[1
]}

Czapla, Norbert ^{[1
]}

Markowska, Marta ^{[1
]}

Petriczko, Jan ^{[1
]}

Kledzik, Jakub ^{[1
]}

Jedrzejczyk-Kledzik, Alicja ^{[1
]}

Palma, Joanna ^{[3
]}

Zabielska, Paulina ^{[4
]}

Maciejewska-Markiewicz, Dominika ^{[2
]}

机构：

[1] Pomeranian Med Univ, Dept Plast Endocrine & Gen Surg, Siedlecka 2, PL-72010 Police, Poland

[2] Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland

[3] Pomeranian Med Univ, Dept Biochem Sci, PL-71460 Szczecin, Poland

[4] Pomeranian Med Univ, Subdept Social Med & Publ Hlth, Dept Social Med, PL-71210 Szczecin, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2021年 / 10卷 / 16期

关键词：

microbiome; thyroid dysfunction; microbiome metabolites; dysbiosis; thyroxine; CHAIN FATTY-ACIDS; GUT MICROBIOTA; HASHIMOTOS-THYROIDITIS; HELICOBACTER-PYLORI; RECEPTOR TGR5; BILE-ACIDS; THYROXINE; DISEASE; ABSORPTION; SELENIUM;

D O I：

10.3390/jcm10163609

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyroid diseases are common conditions that have a negative impact on the health of all populations. The literature sheds light on the differences in the composition of the intestinal microbiota in patients suffering from thyroid diseases compared to healthy individuals. The microbiome affects the proper functioning of the thyroid gland, and the existence of the gut-thyroid axis is discussed in the context of both thyroid diseases and intestinal dysbiosis. The purpose of this review is to describe associations between the microbiome and its metabolites and thyroid dysfunction. We try to explain the role of the microbiome in the metabolism of thyroid hormones and the impact of thyroid autoimmune diseases. In addition, we raise issues related to the influence of bacterial metabolites, such as short-chain fatty acids or secondary bile acids, in the functioning of the thyroid gland. Last but not least, we explored the interactions between the gut microbiota and therapeutics and supplements typically administered to patients with thyroid diseases.

引用

页数：16

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