Early improvements in anxiety, depression, and anger/hostility symptoms and response to antidepressant treatment

被引：0

作者：

Farabaugh, Amy ^{[1
]}

Sonawalla, Shamsah ^{[2
,3
]}

Johnson, Daniel P. ^{[1
]}

Witte, Janet ^{[1
]}

Papakostas, George I. ^{[1
]}

Goodness, Tracie ^{[1
]}

Clain, Alisabet ^{[1
]}

Baer, Lee ^{[1
]}

Mischoulon, David ^{[1
]}

Fava, Maurizio ^{[1
]}

Harley, Rebecca

机构：

[1] Massachusetts Gen Hosp, Depress Clin & Res Program, Dept Psychiat, Boston, MA 02114 USA

[2] Jaslok Hosp & Res Ctr, Mumbai, Maharashtra, India

[3] Duke Univ, Dept Psychiat & Behav Sci, Med Ctr, Durham, NC USA

来源：

ANNALS OF CLINICAL PSYCHIATRY | 2010年 / 22卷 / 03期

关键词：

major depressive disorder; anxiety; hostility; depression; Symptom Questionnaire; FLUOXETINE; PREDICTORS;

D O I：

暂无

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

BACKGROUND: The purpose of this study was to examine whether treatment response to fluoxetine by depressed outpatients was predicted by early improvement on any of 3 subscales (Anxiety, Depression, and Anger/Hostility) of the Symptom Questionnaire (SQ). METHODS: We evaluated 169 depressed outpatients (52.6% female) between ages 18 and 65 (mean age, 40.3 +/- 10.6 years) meeting DSM-III-R criteria for major depressive disorder (MDD). All patients completed the SQ at baseline (week 0) and at weeks 2, 4, and 8 of treatment with fluoxetine 20 mg/d. We defined treatment response as a >= 50% reduction in score on the 17-item Hamilton Rating Scale for Depression, and early improvement on 3 SQ subscales (Anxiety, Depression, and Anger/Hostility) as a >= 30% reduction in score by week 2. RESULTS: The percentage of patients with significant early improvement in anger was significantly greater than the percentage of those with early improvements in anxiety or depression. When early improvement on the Anxiety, Depression, and Anger/Hostility subscales of the SQ were assessed independently by logistic regression, all 3 subscales were predictors of response to treatment. CONCLUSIONS: Early improvement in anger, anxiety, and depressive symptoms may predict response to antidepressant treatment among outpatients with MDD.

引用

页码：166 / 171

页数：6