The effect of family environment and psychiatric family history on psychosocial functioning in first-episode psychosis at baseline and after 2 years

被引：14

作者：

Verdolini, Norma ^{[1
]}

Amoretti, Silvia ^{[2
,3
,4
,5
]}

Mezquida, Gisela ^{[2
,3
,4
,5
]}

Cuesta, Manuel J. ^{[6
]}

Pina-Camacho, Laura ^{[4
,7
,8
]}

Garcia-Rizo, Clemente ^{[2
,3
,4
,5
]}

Lobo, Antonio ^{[9
,10
]}

Gonzalez-Pinto, Ana ^{[11
]}

Merchan-Naranjo, Jessica ^{[4
,7
,8
]}

Corripio, Iluminada ^{[4
,12
]}

Salagre, Estela ^{[1
]}

Baeza, Immaculada ^{[13
]}

Berge, Daniel ^{[4
,14
,15
]}

Garriga, Marina ^{[1
]}

Bioque, Miquel ^{[2
,3
,4
,5
]}

Vallespir, Catalina ^{[1
]}

Serra, Maria ^{[1
]}

Vieta, Eduard ^{[1
]}

Bernardo, Miguel ^{[2
,3
,4
,5
]}

机构：

[1] Univ Barcelona, Inst Neurosci, Hosp Clin, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, 170 Villarroel St, Barcelona 12008036, Catalonia, Spain

[2] Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit, Barcelona, Spain

[3] Univ Barcelona, Inst Neurociencies, Dept Med, Barcelona, Spain

[4] Biomed Res Networking Ctr Mental Hlth Network CI, Barcelona, Spain

[5] August Pi I Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain

[6] Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain

[7] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain

[8] Univ Complutense, Sch Med, Hosp Gen Univ Gregorio Maranon,IiSGM, Inst Psychat & Mental Hlth,Dept Child & Adolescen, Madrid, Spain

[9] Univ Zaragoza, Dept Med & Psychiat, Zaragoza, Spain

[10] Inst Invest Sanit Aragon IIS Aragon, Zaragoza, Spain

[11] Hosp Univ Alava, UPV EHU, BIOARABA, CIBERSAM, Vitoria, Spain

[12] Univ Autonoma Barcelona UAB, Hosp Santa Creu St Pau, Inst Invest Biomed St Pau IIBSANT PAU, Psychiat Dept, Barcelona, Spain

[13] Univ Barcelona, Hosp Clin Barcelona, Clin Inst Neurosci,IDIBAPS, Dept Child & Adolescent Psychiat & Psychol,CIBERS, Barcelona, Spain

[14] Hosp Mar Med Res Inst IMIM, Barcelona, Spain

[15] Autonomous Univ Barcelona UAB, Barcelona, Spain

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2021年 / 49卷

基金：

欧盟地平线“2020”;

关键词：

First-episode psychosis; Family environment; Psychiatric family history; Psychosocial functioning; Non-affective psychoses; Affective psychoses; FOLLOW-UP; 1ST EPISODE; BIPOLAR DISORDER; SCHIZOPHRENIA; PREDICTORS; SYMPTOMS; ONSET; ADOLESCENTS; RECOVERY; ASSOCIATION;

D O I：

10.1016/j.euroneuro.2021.03.015

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of the present study was to evaluate the contribution of family environment styles and psychiatric family history on functioning of patients presenting first-episode psychosis (FEP). Patients with FEP and healthy controls (HC) were assessed at baseline and after 2 years. The Functional Assessment Short Test (FAST) was used to assess functional outcome and the Family Environment Scale (FES) to evaluate family environment. Linear regressions evaluated the effect that family environment exerts on functioning at baseline and at 2-year follow-up, when FEP patients were diagnosed according to non-affective (NA-PSYCH) or affective psychoses (A PSYCH). The influence of a positive parents' psychiatric history on functioning was evaluated through one-way between-groups analysis of covariance (ANCOVA) models, after controlling for family environmental styles. At baseline, FEP patients presented moderate functioning impairment, significantly worse than HC (28.65 +/- 16.17 versus 3.25 +/- 7.92; p < 0.001, g = 1.91). At 2-year follow-up, the functioning of NA-PSYCH patients was significantly worse than in A-PSYCH (19.92 +/- 14.83 versus 12.46 +/- 14.86; p = 0.020, g = 0.50). No specific family environment style was associated with functioning in FEP patients and HC. On the contrary, a positive psychiatric father's history influenced functioning of FEP patients. After 2 years, worse functioning in NA-PSYCH patients was associated with lower rates of active-recreational and achievement orientated family environment and with higher rates of moral-religious emphasis and control. In A-PSYCH, worse functioning was associated with higher rates of conflict in the family. Both family environment and psychiatric history influence psychosocial functioning, with important implications for early interventions, that should involve both patients and caregivers. (c) 2021 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：54 / 68

页数：15

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