CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death

被引：110

作者：

Levy, Yves ^{[1
,2
]}

Wiedemann, Aurelie ^{[1
]}

Hejblum, Boris P. ^{[1
,3
]}

Durand, Melany ^{[1
,3
]}

Lefebvre, Cecile ^{[1
]}

Surenaud, Mathieu ^{[1
]}

Lacabaratz, Christine ^{[1
]}

Perreau, Matthieu ^{[4
]}

Foucat, Emile ^{[1
]}

Dechenaud, Marie ^{[1
]}

Tisserand, Pascaline ^{[1
]}

Blengio, Fabiola ^{[1
]}

Hivert, Benjamin ^{[3
]}

Gauthier, Marine ^{[3
]}

Cervantes-Gonzalez, Minerva ^{[5
,6
,7
]}

Bachelet, Delphine ^{[5
,7
]}

Laouenan, Cedric ^{[5
,7
]}

Bouadma, Lila ^{[8
]}

Timsit, Jean-Francois ^{[8
]}

Yazdanpanah, Yazdan ^{[6
,7
]}

Pantaleo, Giuseppe ^{[1
,4
,9
]}

Hocini, Hakim ^{[1
]}

Thiebaut, Rodolphe ^{[1
,3
,10
]}

机构：

[1] Univ Paris Est Creteil, Hop Henri Mondor, Vaccine Res Inst, Fac Med,INSERM U955,Team 16, 51 Av Marechal Lattre Tassigny, F-94010 Creteil, France

[2] AP HP, Grp Henri Mondor Albert Chenevier, Serv Immunol Clin, Creteil, France

[3] Univ Bordeaux, INSERM U1219 Bordeaux Populat Hlth Res Ctr, Dept Publ Hlth, Inria SISTM,UMR 1219, 146 Rue Leo Saignat, F-33076 Bordeaux, France

[4] Univ Lausanne, Lausanne Univ Hosp, Swiss Vaccine Res Inst, Lausanne, Switzerland

[5] Hop Bichat Claude Bernard, AP HP, INSERM, Ctr Invest Clin Epidemiol Clin 1425,Dept Epidemio, F-75018 Paris, France

[6] Hop Bichat Claude Bernard, AP HP, Serv Malad Infect & Trop, F-75018 Paris, France

[7] Univ Paris, INSERM, IAME UMR 1137, F-75018 Paris, France

[8] Hop Bichat Claude Bernard, AP HP, Med Intens & Reanimat Malad Infect, Paris, France

[9] Univ Lausanne, Lausanne Univ Hosp, Dept Med, Immunol & Allergy Serv, Lausanne, Switzerland

[10] CHU Bordeaux, Pole Sante Publ, Serv Informat Med, Bordeaux, France

来源：

ISCIENCE | 2021年 / 24卷 / 07期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

COVID-19; INFECTION; CYTOKINE; MILD;

D O I：

10.1016/j.isci.2021.102711

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. Higher levels were confirmed in a second cohort and in intensive care unit (ICU) than non-ICU patients (P < 0.001). Longitudinal measurements discriminated between patients with the worst prognosis, leading to death, and those who recovered (P = 0.01). These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care.

引用

页数：20

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