Developments in transgenic technology: applications for medicine

被引：22
作者：
Hunter, CV
Tiley, LS
Sang, HM [1 ]
机构：
[1] Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland
[2] Univ Cambridge, Ctr Vet Sci, Cambridge CB3 0ES, England
来源：
TRENDS IN MOLECULAR MEDICINE | 2005年 / 11卷 / 06期
基金：
英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1016/j.molmed.2005.04.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent advances in the efficiency of transgenic technology have important implications for medicine. The production of therapeutic proteins from animal bioreactors is well established and the first products are close to market. The genetic modification of pigs to improve their suitability as organ donors for xenotransplantation has been initiated, but many challenges remain. The use of transgenesis, in combination with the method of RNA interference to knock down gene expression, has been proposed as a method for making animals resistant to viral diseases, which could reduce the likelihood of transmission to humans. Here, the latest developments in transgenic technology and their applications relevant to medicine and human health will be discussed.
引用
收藏
页码：293 / 298
页数：6
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