Direct organocatalytic α-fluorination of aldehydes and ketones

被引：176

作者：

Enders, D ^{[1
]}

Hüttl, MRM ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

SYNLETT | 2005年 / 06期

关键词：

organocatalysis; Selectfluor; electrophilic fluorination; aldehydes; ketones;

D O I：

10.1055/s-2005-864813

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first organocatalytic direct alpha-fluorination of aldehydes and ketones employing Selectfluor {1-chloromethyl-4-fluoro- 1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)} as the fluorine source is reported. (S)-Proline and related derivatives act as organocatalysts to give the corresponding alpha-fluoroaldehydes and alpha-fluoroketones in moderate to good yields (47-78%). The asymmetric inductions are still low (ee <= 36%).

引用

页码：991 / 993

页数：3

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