Effectiveness of corticosteroids on immune checkpoint inhibitor-induced interstitial pneumonia among patients with a history of interstitial pneumonia: A case series

被引：2

作者：

Ichimura, Takenori ^{[1
,2
]}

Hinata, Miwa ^{[1
,2
]}

Ichikural, Daisuke ^{[1
,2
]}

Suzuki, Shinya ^{[1
]}

机构：

[1] Showa Univ, Dept Hosp Pharmaceut, Sch Pharm, Tokyo, Japan

[2] Showa Univ, Dept Pharm Serv, Northern Yokohama Hosp, Yokohama, Kanagawa, Japan

来源：

SAGE OPEN MEDICAL CASE REPORTS | 2021年 / 9卷

关键词：

Interstitial pneumonia; immune checkpoint inhibitors; corticosteroids; CANCER-PATIENTS; DOCETAXEL; NIVOLUMAB;

D O I：

10.1177/2050313X211031313

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There are few reports on the effectiveness of corticosteroids for immune checkpoint inhibitor-induced interstitial pneumonia in patients with a history of interstitial pneumonia. We report on 10 non-small cell lung cancer patients with a history of interstitial pneumonia who experienced immune checkpoint inhibitor-induced interstitial pneumonia. The immune checkpoint inhibitor-induced interstitial pneumonia lasted for a median duration of 41.5 days (range = 22-127 days). Eight of the ten patients responded to corticosteroid monotherapy; one patient responded to corticosteroids and the immunosuppressant, tacrolimus; and one patient did not improve after corticosteroid treatment. In non-small cell lung cancer patients with a history of interstitial pneumonia, immune checkpoint inhibitor-induced interstitial pneumonia was generally responds to corticosteroids.

引用

页数：5

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