Kilogram-Scale Pilot Synthesis of Fingolimod

被引：2

作者：

Balaev, A. N. ^{[1
]}

Busel, A. A. ^{[1
]}

Fedorov, V. E. ^{[1
]}

机构：

[1] Farm Sintez Co, 29-134 Vereiskaya St, Moscow 121357, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 51卷 / 06期

关键词：

fingolimod; pilot synthesis; S1P receptor modulator; IMMUNOSUPPRESSIVE AGENT FTY720;

D O I：

10.1007/s11094-017-1636-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A kilogram-scale synthesis of fingolimod drug substance was developed using a 30-L pilot setup. The target product was obtained by a four-step procedure in 99.8% purity and 47% overall yield.

引用

页码：476 / 479

页数：4