Functional genomics approaches to studies of the cytochrome P450 superfamily

被引：11

作者：

Rezen, Tadeja ^{[1
]}

Contreras, Juan A. ^{[1
]}

Rozman, Damjana ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Med, Inst Biochem, Ctr Funct Genom & Bio Chips, SI-1000 Ljubljana, Slovenia

来源：

DRUG METABOLISM REVIEWS | 2007年 / 39卷 / 2-3期

关键词：

functional genomics; microarray; genomics; cytochrome P450; proteomics; steroltalk; pharmacogenomics; toxicogenomics;

D O I：

10.1080/03602530701498760

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Functional genoinics approaches are widely implemented in current research and have found application in many areas of biology. This review will present research fields, novel findings and new tools developed in the cytochrome P450 field using the functional genomics techniques. The most widely used method is microarray technology, which has already greatly contributed to the understanding of the cytochromes P450 function and expression. Several focused CYP microarrays have been developed for genotyping, toxicogenomics and studies of CYP function of many different organisms. Our contribution to the CYP field by development of Steroltalk microarrays to study the cross-talk of cholesterol homeostasis and drug metabolism is also presented.

引用

页码：389 / 399

页数：11

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