Aspects of Gut Microbiota and Immune System Interactions in Infectious Diseases, Immunopathology, and Cancer

被引：369

作者：

Lazar, Veronica ^{[1
,2
]}

Ditu, Lia-Mara ^{[1
,2
]}

Pircalabioru, Gratiela Gradisteanu ^{[1
,2
]}

Gheorghe, Irina ^{[1
,2
]}

Curutiu, Carmen ^{[1
,2
]}

Holban, Alina Maria ^{[1
,2
]}

Picu, Ariana ^{[1
,3
]}

Petcu, Laura ^{[1
,3
]}

Chifiriuc, Mariana Carmen ^{[1
,2
]}

机构：

[1] Univ Bucharest, Dept Microbiol & Immunol, Fac Biol, Bucharest, Romania

[2] Univ Bucharest, Earth Environm & Life Sci Sect, Res Inst, Bucharest, Romania

[3] Natl Inst Diabet Nutr & Metab Dis Prof Dr N Paule, Bucharest, Romania

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

关键词：

gut microbiota; opportunistic infections; autoimmunity; chronic inflammation; cancer; antibiotics; probiotics; diet; STREPTOCOCCUS-ANGINOSUS INFECTION; INFLAMMATORY-BOWEL-DISEASE; SQUAMOUS-CELL CARCINOMA; TOLL-LIKE RECEPTORS; CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; COLORECTAL-CANCER; ESCHERICHIA-COLI; EPITHELIAL-CELLS; GASTRIC-CANCER;

D O I：

10.3389/fimmu.2018.01830

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea, and protozoans, bringing to the host organism a dowry of cells and genes more numerous than its own. Among the different non-sterile cavities, the human gut harbors the most complex microbiota, with a strong impact on host homeostasis and immunostasis, being thus essential for maintaining the health condition. In this review, we outline the roles of gut microbiota in immunity, starting with the background information supporting the further presentation of the implications of gut microbiota dysbiosis in host susceptibility to infections, hypersensitivity reactions, autoimmunity, chronic inflammation, and cancer. The role of diet and antibiotics in the occurrence of dysbiosis and its pathological consequences, as well as the potential of probiotics to restore eubiosis is also discussed.

引用

页数：18

共 216 条

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