Can protein biomarkers provide an index of coronary artery calcification in patients with Type 2 diabetes?

被引：11

作者：

Godsland, I. F. ^{[1
]}

Pavitt, D. ^{[1
]}

Okoturo, O. ^{[1
]}

Edwards, R. J. ^{[1
]}

Rubens, M. B. ^{[2
]}

Feher, M. D. ^{[3
]}

Flather, M. D. ^{[4
]}

Elkeles, R. S. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, London W2 1NY, England

[2] Royal Brompton Hosp, CT Scanning Unit, London SW3 6LY, England

[3] Chelsea & Westminster Hosp, Beta Cell Unit, London, England

[4] Royal Brompton Hosp, Clin Trials & Evaluat Unit, London SW3 6LY, England

来源：

ATHEROSCLEROSIS | 2010年 / 213卷 / 02期

关键词：

Coronary artery calcification; Proteomics; Biomarkers; SELDI-TOF mass spectrometry; C-REACTIVE PROTEIN; COMPUTED-TOMOGRAPHY; HEART-DISEASE;

D O I：

10.1016/j.atherosclerosis.2010.09.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: By exploring differences between patients with high and low coronary artery calcification score (CACS), a plasma protein biomarker might be identified as an alternative to CACS screening. Methods: We selected stored samples (12 per group) from a cohort study of patients with Type 2 diabetes and CACS > 1000 or < 100 Agatston units, with matching for age, BMI, blood pressure, lipids and lipoproteins and fibrinogen. Multiplex, immunobead-based assay or ELISA measured 18 cardiovascular-related protein biomarkers. SELDI-TOF mass spectrometry (MS) screened for proteins differing significantly between high and low CACS. Results: Only monocyte chemotactic protein-1 was higher in the high compared with the low CACS group but concentrations overlapped appreciably. On SELDI-TOF MS, several mass/charge ratio peak intensities significantly discriminated high and low CACS but these differences were not confirmed in larger samples from the cohort. Conclusions: Plasma protein biomarkers are unlikely to provide an effective alternative to measurement of CACS. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：570 / 572

页数：3

共 13 条

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