Can protein biomarkers provide an index of coronary artery calcification in patients with Type 2 diabetes?

被引：11
作者：
Godsland, I. F. [1 ]
Pavitt, D. [1 ]
Okoturo, O. [1 ]
Edwards, R. J. [1 ]
Rubens, M. B. [2 ]
Feher, M. D. [3 ]
Flather, M. D. [4 ]
Elkeles, R. S. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, London W2 1NY, England
[2] Royal Brompton Hosp, CT Scanning Unit, London SW3 6LY, England
[3] Chelsea & Westminster Hosp, Beta Cell Unit, London, England
[4] Royal Brompton Hosp, Clin Trials & Evaluat Unit, London SW3 6LY, England
来源：
ATHEROSCLEROSIS | 2010年 / 213卷 / 02期
关键词：
Coronary artery calcification; Proteomics; Biomarkers; SELDI-TOF mass spectrometry; C-REACTIVE PROTEIN; COMPUTED-TOMOGRAPHY; HEART-DISEASE;
D O I：
10.1016/j.atherosclerosis.2010.09.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: By exploring differences between patients with high and low coronary artery calcification score (CACS), a plasma protein biomarker might be identified as an alternative to CACS screening. Methods: We selected stored samples (12 per group) from a cohort study of patients with Type 2 diabetes and CACS > 1000 or < 100 Agatston units, with matching for age, BMI, blood pressure, lipids and lipoproteins and fibrinogen. Multiplex, immunobead-based assay or ELISA measured 18 cardiovascular-related protein biomarkers. SELDI-TOF mass spectrometry (MS) screened for proteins differing significantly between high and low CACS. Results: Only monocyte chemotactic protein-1 was higher in the high compared with the low CACS group but concentrations overlapped appreciably. On SELDI-TOF MS, several mass/charge ratio peak intensities significantly discriminated high and low CACS but these differences were not confirmed in larger samples from the cohort. Conclusions: Plasma protein biomarkers are unlikely to provide an effective alternative to measurement of CACS. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：570 / 572
页数：3
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