Genome-wide analysis reveals the effects of artificial selection on production and meat quality traits in Qinchuan cattle

被引：38

作者：

Mei, Chugang ^{[1
]}

Wang, Hongcheng ^{[1
,2
]}

Liao, Qijun ^{[3
]}

Khan, Rajwali ^{[1
]}

Raza, Sayed Haidar Abbas ^{[1
]}

Zhao, Chunping ^{[1
]}

Wang, Hongbao ^{[1
]}

Cheng, Gong ^{[1
]}

Tian, Wanqiang ^{[4
]}

Li, Yaokun ^{[5
]}

Zan, Linsen ^{[1
,6
]}

机构：

[1] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

[2] Guizhou Normal Univ, Coll Life Sci, Guiyang 550001, Guizhou, Peoples R China

[3] BGI Shenzhen, BGI Genom, Shenzhen 518083, Peoples R China

[4] Yangling Vocat & Tech Coll, Yangling 712100, Shaanxi, Peoples R China

[5] South China Agr Univ, Coll Anim Sci & Technol, Guangzhou 510642, Guangdong, Peoples R China

[6] Natl Beef Cattle Improvement Ctr, Yangling 712100, Shaanxi, Peoples R China

来源：

GENOMICS | 2019年 / 111卷 / 06期

关键词：

Qinchuan cattle; Genome sequencing; Breeding; Selection; RII-BETA-SUBUNIT; GENE-EXPRESSION; READ ALIGNMENT; WHOLE; POLYMORPHISMS; ASSOCIATION; RECEPTOR;

D O I：

10.1016/j.ygeno.2018.09.021

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new strain of Qinchuan cattle (QNS) has been obtained after more than forty years of selective breeding, and it shows good performance and production traits. To characterize the genetic changes that have resulted from breeding, we sequenced 10 QNS and 10 of the original breed Qinchuan cattle (QCC) for the first time, with average of 12.5-fold depth. A total of 31,242,284 and 29,612,517 SNPs were identified in the QCC and QNS genomes, 47.81% and 44.36% of which were found to be novel, respectively. Furthermore, population structure analysis revealed the selection that these cattle had experienced. Then, 332 and 571 potential selected genes were obtained, associated with enhanced immunity and acclimatization in QCC (CD5, SMARCA2, CATHL2, etc.) and production or meat quality traits in QNS (PLCD3, MB, PPARGC1A, etc.). These results revealed the efforts of selective breeding for Chinese Qinchuan cattle, and will be helpful for future cattle breeding.

引用

页码：1201 / 1208

页数：8

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