Hydroxyl radical-mediated modification of proteins as probes for structural proteomics

被引：577
作者：
Xu, Guozhong [1 ]
Chance, Mark R. [1 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Ctr Proteom, Cleveland, OH 44106 USA
来源：
CHEMICAL REVIEWS | 2007年 / 107卷 / 08期
基金：
欧盟地平线“2020”;
关键词：
D O I：
10.1021/cr0682047
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A review on the comprehensive reference work to better understand the chemistry of radical generation and oxidative reactions are presented that are used for structural mass spectrometry experiments. In addition, several topics discussed include the generation of hydroxyl radicals in solution and the hydroxyl radical mediated cleavage of the main chain and modification of side chains.
引用
收藏
页码：3514 / 3543
页数：30
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