Genomic complexity and IGHV mutational status are key predictors of outcome of chronic lymphocytic leukemia patients with TP53 disruption

被引：32

作者：

Delgado, Julio ^{[1
]}

Salaverria, Itziar ^{[2
]}

Baumann, Tycho ^{[1
]}

Martinez-Trillos, Alejandra ^{[2
]}

Lee, Eriong ^{[2
]}

Jimenez, Laura ^{[2
]}

Navarro, Alba ^{[2
]}

Royo, Cristina ^{[2
]}

Santacruz, Rodrigo ^{[1
]}

Lopez, Cristina ^{[2
]}

Payer, Angel R. ^{[3
]}

Colado, Enrique ^{[3
]}

Gonzalez, Marcos ^{[4
]}

Armengol, Lluis ^{[5
]}

Colomer, Dolors ^{[2
]}

Pinyol, Magda ^{[2
]}

Villamor, Neus ^{[2
]}

Aymerich, Marta ^{[2
]}

Carrio, Ana ^{[2
]}

Costa, Dolors ^{[2
]}

Clot, Guillem ^{[2
]}

Gine, Eva ^{[1
]}

Lopez-Guillermo, Armando ^{[1
]}

Campo, Elias ^{[2
]}

Bea, Silvia ^{[2
]}

机构：

[1] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Hosp Clin, Dept Hematol, Barcelona, Spain

[2] IDIBAPS, Hosp Clin, Hematopathol Unit, Barcelona, Spain

[3] Univ Oviedo, Hosp Cent Asturias, Dept Hematol, E-33080 Oviedo, Spain

[4] Hosp Clin Salamanca, Dept Hematol, Salamanca, Spain

[5] qGen Labs, Barcelona, Spain

来源：

HAEMATOLOGICA | 2014年 / 99卷 / 11期

关键词：

CLL; TP53; IGHV; 17p deletion; CN; arrays; genome complexity; IDENTIFIES RECURRENT MUTATIONS; ERIC RECOMMENDATIONS; 17P DELETION; SURVIVAL; SF3B1; GENE;

D O I：

10.3324/haematol.2014.108365

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页数：4

共 15 条

[1] Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial [J].

Catovsky, D. ;

Richards, S. ;

Matutes, E. ;

Oscier, D. ;

Dyer, M. J. S. ;

FBezares, R. ;

Pettitt, A. R. ;

Hamblin, T. ;

Milligan, D. W. ;

Child, J. A. ;

Hamilton, M. S. ;

Dearden, C. E. ;

Smith, A. G. ;

Bosanquet, A. G. ;

Davis, Z. ;

Brito-Babapulle, V. ;

Else, M. ;

Wade, R. ;

Hillmen, P. .

LANCET, 2007, 370 (9583) :230-239

[2] Chronic lymphocytic leukaemia with 17p deletion: a retrospective analysis of prognostic factors and therapy results [J].

Delgado, Julio ;

Espinet, Blanca ;

Oliveira, Ana C. ;

Abrisqueta, Pau ;

de la Serna, Javier ;

Collado, Rosa ;

Loscertales, Javier ;

Lopez, Montserrat ;

Hernandez-Rivas, Jose A. ;

Ferra, Christelle ;

Ramirez, Angel ;

Roncero, Josep M. ;

Lopez, Cristina ;

Aventin, Anna ;

Puiggros, Anna ;

Abella, Eugenia ;

Carbonell, Felix ;

Costa, Dolors ;

Carrio, Anna ;

Gonzalez, Marcos .

BRITISH JOURNAL OF HAEMATOLOGY, 2012, 157 (01) :67-74

[3] Genomic aberrations and survival in chronic lymphocytic leukemia. [J].

Döhner, H ;

Stilgenbauer, S ;

Benner, A ;

Leupolt, E ;

Kröber, A ;

Bullinger, L ;

Döhner, K ;

Bentz, M ;

Lichter, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (26) :1910-1916

[4] Genome-wide DNA analysis identifies recurrent imbalances predicting outcome in chronic lymphocytic leukaemia with 17p deletion [J].

Forconi, Francesco ;

Rinaldi, Andrea ;

Kwee, Ivo ;

Sozzi, Elisa ;

Raspadori, Donatella ;

Rancoita, Paola M. V. ;

Scandurra, Marta ;

Rossi, Davide ;

Deambrogi, Clara ;

Capello, Daniela ;

Zucca, Emanuele ;

Marconi, Daniela ;

Bomben, Riccardo ;

Gattei, Valter ;

Lauria, Francesco ;

Gaidano, Gianluca ;

Bertoni, Francesco .

BRITISH JOURNAL OF HAEMATOLOGY, 2008, 143 (04) :532-536

[5] ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia [J].

Ghia, P. ;

Stamatopoulos, K. ;

Belessi, C. ;

Moreno, C. ;

Stilgenbauer, S. ;

Stevenson, F. ;

Davi, F. ;

Rosenquist, R. .

LEUKEMIA, 2007, 21 (01) :1-3

[6] Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia [J].

Gunnarsson, Rebeqa ;

Mansouri, Larry ;

Isaksson, Anders ;

Goransson, Hanna ;

Cahill, Nicola ;

Jansson, Mattias ;

Rasmussen, Markus ;

Lundin, Jeanette ;

Norin, Stefan ;

Buhl, Anne Mette ;

Smedby, Karin Ekstrom ;

Hjalgrim, Henrik ;

Karlsson, Karin ;

Jurlander, Jesper ;

Geisler, Christian ;

Juliusson, Gunnar ;

Rosenquist, Richard .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2011, 96 (08) :1161-1169

[7] PROGNOSTIC SUBGROUPS IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA DEFINED BY SPECIFIC CHROMOSOMAL-ABNORMALITIES [J].

JULIUSSON, G ;

OSCIER, DG ;

FITCHETT, M ;

ROSS, FM ;

STOCKDILL, G ;

MACKIE, MJ ;

PARKER, AC ;

CASTOLDI, GL ;

CUNEO, A ;

KNUUTILA, S ;

ELONEN, E ;

GAHRTON, G .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (11) :720-724

[8] Acquired genomic copy number aberrations and survival in chronic lymphocytic leukemia [J].

Ouillette, Peter ;

Collins, Roxane ;

Shakhan, Sajid ;

Li, Jinghui ;

Peres, Edward ;

Kujawski, Lisa ;

Talpaz, Moshe ;

Kaminski, Mark ;

Li, Cheng ;

Shedden, Kerby ;

Malek, Sami N. .

BLOOD, 2011, 118 (11) :3051-3061

[9] ERIC recommendations on TP53 mutation analysis in chronic lymphocytic leukemia [J].

Pospisilova, S. ;

Gonzalez, D. ;

Malcikova, J. ;

Trbusek, M. ;

Rossi, D. ;

Kater, A. P. ;

Cymbalista, F. ;

Eichhorst, B. ;

Hallek, M. ;

Doehner, H. ;

Hillmen, P. ;

van Oers, M. ;

Gribben, J. ;

Ghia, P. ;

Montserrat, E. ;

Stilgenbauer, S. ;

Zenz, T. .

LEUKEMIA, 2012, 26 (07) :1458-1461

[10] Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia [J].

Puente, Xose S. ;

Pinyol, Magda ;

Quesada, Victor ;

Conde, Laura ;

Ordonez, Gonzalo R. ;

Villamor, Neus ;

Escaramis, Georgia ;

Jares, Pedro ;

Bea, Silvia ;

Gonzalez-Diaz, Marcos ;

Bassaganyas, Laia ;

Baumann, Tycho ;

Juan, Manel ;

Lopez-Guerra, Monica ;

Colomer, Dolors ;

Tubio, Jose M. C. ;

Lopez, Cristina ;

Navarro, Alba ;

Tornador, Cristian ;

Aymerich, Marta ;

Rozman, Maria ;

Hernandez, Jesus M. ;

Puente, Diana A. ;

Freije, Jose M. P. ;

Velasco, Gloria ;

Gutierrez-Fernandez, Ana ;

Costa, Dolors ;

Carrio, Anna ;

Guijarro, Sara ;

Enjuanes, Anna ;

Hernandez, Lluis ;

Yaguee, Jordi ;

Nicolas, Pilar ;

Romeo-Casabona, Carlos M. ;

Himmelbauer, Heinz ;

Castillo, Ester ;

Dohm, Juliane C. ;

de Sanjose, Silvia ;

Piris, Miguel A. ;

de Alava, Enrique ;

Miguel, Jesus San ;

Royo, Romina ;

Gelpi, Josep L. ;

Torrents, David ;

Orozco, Modesto ;

Pisano, David G. ;

Valencia, Alfonso ;

Guigo, Roderic ;

Bayes, Monica ;

Heath, Simon .

NATURE, 2011, 475 (7354) :101-105

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