Biomarkers of aging in real life: three questions on aging and the comprehensive geriatric assessment

被引：42

作者：

Zampino, Marta ^{[1
]}

Polidori, M. Cristina ^{[2
,3
,4
]}

Ferrucci, Luigi ^{[1
]}

O'Neill, Desmond ^{[5
,6
]}

Pilotto, Alberto ^{[7
,8
]}

Gogol, Manfred ^{[9
,10
]}

Rubenstein, Laurence ^{[11
]}

机构：

[1] Natl Inst Aging, Natl Inst Hlth, Longitudinal Studies Sect, Translat Gerontol Branch, Baltimore, MD USA

[2] Univ Cologne, Aging Clin Res, Dept Internal Med 2, Cologne, Germany

[3] Univ Cologne, Ctr Mol Med Cologne, Fac Med, Univ Hosp Cologne, Cologne, Germany

[4] Univ Cologne, Cologne Excellence Cluster Cellular Stress, Responses Aging Associated Dis CECAD, Fac Med,Univ Hosp Cologne, Cologne, Germany

[5] Tallaght Univ Hosp, Dublin, Ireland

[6] Trinity Coll Dublin, Tallaght Univ Hosp, Trinity Ctr Hlth Sci, Dublin, Ireland

[7] Galliera Hosp, Dept Geriatr Care Orthogeriatr & Rehabil, Geriatr Unit, Genoa, Italy

[8] Univ Bari, Dept Interdisciplinary Med, Bari, Italy

[9] Hannover Med Sch, Trauma Dept, Orthogeriatr Unit, Hannover, Germany

[10] Heidelberg Univ, Inst Gerontol, Heidelberg, Germany

[11] Univ Oklahoma, Dept Geriatr Med, Oklahoma City, OK USA

来源：

GEROSCIENCE | 2022年 / 44卷 / 06期

关键词：

Biological aging; Comprehensive geriatric assessment; Multidimensional prognostic index; Frailty; MULTIDIMENSIONAL PROGNOSTIC INDEX; COMMUNITY-ACQUIRED PNEUMONIA; FRAIL OLDER PATIENTS; ALL-CAUSE MORTALITY; LENGTH-OF-STAY; CLINICAL-PRACTICE; TERM MORTALITY; ASSESSMENT CGA; ADULTS; OUTCOMES;

D O I：

10.1007/s11357-022-00613-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Measuring intrinsic, biological age is a central question in medicine, which scientists have been trying to answer for decades. Age manifests itself differently in different individuals, and chronological age often does not reflect such heterogeneity of health and function. We discuss here the value of measuring age and aging using the comprehensive geriatric assessment (CGA), cornerstone of geriatric medicine, and operationalized assessment tools for prognosis. Specifically, we review the benefits of employing the multidimensional prognostic index (MPI), which collects information about eight domains relevant for the global assessment of the older person (functional and cognitive status, nutrition, mobility and risk of pressure sores, multi-morbidity, polypharmacy, and co-habitation), in the evaluation of the functional status, and in the prediction of health outcomes for older adults. Further integration of biological markers of aging into multidimensional prognostic tools is warranted, as well as actions which could facilitate prognostic assessments for older persons in all healthcare settings.

引用

页码：2611 / 2622

页数：12

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