Ambient Air Pollutions Are Associated with Vitamin D Status

被引:13
作者
Yang, Chenlu [1 ]
Li, Dankang [2 ]
Tian, Yaohua [2 ]
Wang, Peiyu [3 ]
机构
[1] Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 38 Xueyuan Rd, Beijing 100191, Peoples R China
[2] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Maternal & Child Hlth, 13 Hangkong Rd, Wuhan 430030, Peoples R China
[3] Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, 38 Xueyuan Rd, Beijing 100191, Peoples R China
基金
英国医学研究理事会;
关键词
air pollution; vitamin D; UK cohort; USE REGRESSION-MODELS; D DEFICIENCY; UV EXPOSURE; POLLUTANTS; HEALTH; IMPACT; AREAS;
D O I
10.3390/ijerph18136887
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Evidence on the effect of ambient air pollution on vitamin D is limited. This study aimed to examine the association of air pollution exposure with serum levels of 25-hydroxyvitamin D (25OHD) using UK Biobank health datasets. A total of 448,337 subjects were included in this analysis. Land Use Regression was applied to assess individual exposures to particulate matter with diameters <= 2.5 mu m (PM2.5), <= 10 mu m (PM10), nitrogen dioxide (NO2), and nitrogen oxides (NOx). Linear regression models evaluated the associations between air pollutants and serum vitamin D levels after adjustment of a series of confounders. All analyzed air pollutants were negatively associated with serum vitamin 25OHD levels. After adjusting for potential confounders, a 10 mu g/m(3) increase in concentrations of PM2.5, PM10, NOx, and NO2 was associated with -9.11 (95%CI: -13.25 to -4.97), -2.47 (95%CI: -4.51 to -0.43), -0.56 (95%CI: -0.82 to -0.30), and -1.64 (95%CI: -2.17 to -1.10) nmol/L decrease in serum vitamin 25OHD levels, respectively. Interaction analyses suggested that the effects of air pollution were more pronounced in females. In conclusion, long-term exposures to ambient PM2.5, PM10, NOx, and NO2 were associated with vitamin D status in a large UK cohort.
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页数:8
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