A novel anti-rheumatic drug suppresses tumor necrosis factor-α and augments interleukin-10 in adjuvant arthritic rats

被引：23

作者：

Hisadome, M ^{[1
]}

Fukuda, T ^{[1
]}

Sumichika, H ^{[1
]}

Hanano, T ^{[1
]}

Adachi, K ^{[1
]}

机构：

[1] Welfide Corp, Res Labs, Yoshitomi, Fukuoka 8718550, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2000年 / 409卷 / 03期

关键词：

Y-39041; arthritis; TNF-alpha (tumor necrosis factor-alpha); interleukin-10; lipopolysaccharide;

D O I：

10.1016/S0014-2999(00)00866-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tumor necrosis factor-alpha (TNF-alpha) plays an important role in the pathology of rheumatoid arthritis. When N-[1-(4-([4-(pyrimidin-2-yl)piperazin-1-yl]methyl)phenyl)cyclopropyl]acetamide (Y-39041) (3-30 mg/kg) was orally administered to rats with established arthritis from day 15 to day 20, hindpaw volume was significantly reduced. This inhibitory activity of Y-39041 was kept up after administration was stopped. On day 17 Y-39041 suppressed lipopolysaccharide-induced TNF-alpha and interleukin-6 production in serum at doses of 3-30 mg/kg, and augmented interleukin-10 production at doses of 10 and 30 mg/kg. The finding that Y-39041 suppresses TNF-alpha and interleukin-6 production and augments interleukin-10 production could be beneficial in the therapy of chronic inflammatory diseases. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：331 / 335

页数：5

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