Fungal Recognition and Host Defense Mechanisms

被引：26

作者：

Dambuza, I. M. ^{[1
]}

Levitz, S. M. ^{[2
]}

Netea, M. G. ^{[3
,4
]}

Brown, G. D. ^{[1
]}

机构：

[1] Univ Aberdeen, Inst Med Sci, Aberdeen Fungal Grp, MRC Ctr Med Mycol, Aberdeen AB252ZD, Scotland

[2] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA

[3] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Radboud Ctr Infect Dis RCI, Nijmegen, Netherlands

来源：

MICROBIOLOGY SPECTRUM | 2017年 / 5卷 / 04期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

NEUTROPHIL EXTRACELLULAR TRAPS; ANTIMICROBIAL PEPTIDE LL-37; TH17; CELL-DIFFERENTIATION; BETA-GLUCAN RECOGNITION; CANDIDA-ALBICANS; PATTERN-RECOGNITION; NLRP3; INFLAMMASOME; LECTIN RECEPTORS; RIG-I; PNEUMOCYSTIS-CARINII;

D O I：

10.1128/microbiolspec.FUNK-0050-2016

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Fungi have emerged as premier opportunistic microbes of the 21st century, having a considerable impact on human morbidity and mortality. The huge increase in incidence of these diseases is largely due to the HIV pandemic and use of immunosuppressive therapies, underscoring the importance of the immune system in defense against fungi. This article will address how the mammalian immune system recognizes and mounts a defense against medically relevant fungal species.

引用

页数：16

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