Adipose Tissue-Derived Stem Cells: Immunomodulatory Effects and Therapeutic Potential

被引：120
作者：
Al-Ghadban, Sara [1 ]
Bunnell, Bruce A. [1 ,2 ]
机构：
[1] Tulane Univ, Sch Med, Ctr Stem Cell Res & Regenerat Med, 1430 Tulane Ave, New Orleans, LA 70112 USA
[2] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA
来源：
PHYSIOLOGY | 2020年 / 35卷 / 02期
关键词：
adipose-derived stem cells; stromal vascular fraction; immune cells; cytokines; mechanisms of action; immunological disease; STROMAL-VASCULAR FRACTION; VERSUS-HOST-DISEASE; REGULATORY T-CELLS; HUMAN BONE-MARROW; EPITHELIAL DIFFERENTIATION; ENDOTHELIAL-CELLS; SUBCUTANEOUS FAT; CARDIAC-FUNCTION; IN-VIVO; EXOSOMES;
D O I：
10.1152/physiol.00021.2019
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Adipose-derived stem cells (ASCs) can self-renew and differentiate along multiple cell lineages. ASCs are also potently anti-inflammatory due to their inherent ability to regulate the immune system by secreting anti-inflammatory cytokines and growth factors that play a crucial role in the pathology of many diseases, including multiple sclerosis, diabetes mellitus, Crohn's, SLE, and graft-versus-host disease. The immunomodulatory effects and mechanisms of action of ASCs on pathological conditions are reviewed here.
引用
收藏
页码：125 / 133
页数：9
相关论文
共 108 条
[51]   Combination of MSC spheroids wrapped within autologous composite sheet dually protects against immune rejection and enhances stem cell transplantation efficacy [J].
Kim, SangMin ;
Han, Yong-Seok ;
Lee, Jun Hee ;
Lee, Sang Hun .
TISSUE & CELL, 2018, 53 :93-103
[52]   Wound heating effect of adipose-derived stem cells: A critical role of secretory factors on human dermal fibroblasts [J].
Kim, Won-Serk ;
Park, Byung-Soon ;
Sung, Jong-Hyuk ;
Yang, Jun-Mo ;
Park, Seok-Beom ;
Kwak, Sahng-June ;
Park, Jeong-Soo .
JOURNAL OF DERMATOLOGICAL SCIENCE, 2007, 48 (01) :15-24
[53]   The Effect of Age on Osteogenic and Adipogenic Differentiation Potential of Human Adipose Derived Stromal Stem Cells (hASCs) and the Impact of Stress Factors in the Course of the Differentiation Process [J].
Kornicka, Katarzyna ;
Marycz, Krzysztof ;
Tomaszewski, Krzysztof Andrzej ;
Maredziak, Monika ;
Smieszek, Agnieszka .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2015, 2015
[54]   Current Perspectives Regarding Stem Cell-Based Therapy for Liver Cirrhosis [J].
Kwak, Kyeong-Ah ;
Cho, Hyun-Jae ;
Yang, Jin-Young ;
Park, Young-Seok .
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2018, 2018
[55]   Allogeneic adipose-derived stem cells suppress Th17 lymphocytes in patients with active lupus in vitro [J].
Lai, Kuan ;
Zeng, Kang ;
Zeng, Fanqin ;
Wei, Jing ;
Tan, Guozhen .
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2011, 43 (10) :805-812
[56]   Mesenchymal stem cell exosomes [J].
Lai, Ruenn Chai ;
Yeo, Ronne Wee Yeh ;
Lim, Sai Kiang .
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2015, 40 :82-88
[57]   Exosomes for drug delivery - a novel application for the mesenchymal stem cell [J].
Lai, Ruenn Chai ;
Yeo, Ronne Wee Yeh ;
Tan, Kok Hian ;
Lim, Sai Kiang .
BIOTECHNOLOGY ADVANCES, 2013, 31 (05) :543-551
[58]   Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue [J].
Lee, RH ;
Kim, B ;
Choi, I ;
Kim, H ;
Choi, HS ;
Suh, K ;
Bae, YC ;
Jung, JS .
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2004, 14 (4-6) :311-324
[59]   Autologous Adipose Tissue-Derived Stem Cells Treatment Demonstrated Favorable and Sustainable Therapeutic Effect for Crohn's Fistula [J].
Lee, Woo Yong ;
Park, Kyu Joo ;
Cho, Yong Beom ;
Yoon, Sang Nam ;
Song, Kee Ho ;
Kim, Do Sun ;
Jung, Sang Hun ;
Kim, Mihyung ;
Yoo, Hee-Won ;
Kim, Inok ;
Ha, Hunjoo ;
Yu, Chang Sik .
STEM CELLS, 2013, 31 (11) :2575-2581
[60]   The Use of Human Mesenchymal Stem Cells as Therapeutic Agents for the in vivo Treatment of Immune-Related Diseases: A Systematic Review [J].
Leyendecker, Alessander, Jr. ;
Gomes Pinheiro, Carla Cristina ;
Amano, Mariane Tami ;
Bueno, Daniela Franco .
FRONTIERS IN IMMUNOLOGY, 2018, 9
12345678910