Adipose Tissue-Derived Stem Cells: Immunomodulatory Effects and Therapeutic Potential

被引：120
作者：
Al-Ghadban, Sara [1 ]
Bunnell, Bruce A. [1 ,2 ]
机构：
[1] Tulane Univ, Sch Med, Ctr Stem Cell Res & Regenerat Med, 1430 Tulane Ave, New Orleans, LA 70112 USA
[2] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA
来源：
PHYSIOLOGY | 2020年 / 35卷 / 02期
关键词：
adipose-derived stem cells; stromal vascular fraction; immune cells; cytokines; mechanisms of action; immunological disease; STROMAL-VASCULAR FRACTION; VERSUS-HOST-DISEASE; REGULATORY T-CELLS; HUMAN BONE-MARROW; EPITHELIAL DIFFERENTIATION; ENDOTHELIAL-CELLS; SUBCUTANEOUS FAT; CARDIAC-FUNCTION; IN-VIVO; EXOSOMES;
D O I：
10.1152/physiol.00021.2019
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Adipose-derived stem cells (ASCs) can self-renew and differentiate along multiple cell lineages. ASCs are also potently anti-inflammatory due to their inherent ability to regulate the immune system by secreting anti-inflammatory cytokines and growth factors that play a crucial role in the pathology of many diseases, including multiple sclerosis, diabetes mellitus, Crohn's, SLE, and graft-versus-host disease. The immunomodulatory effects and mechanisms of action of ASCs on pathological conditions are reviewed here.
引用
收藏
页码：125 / 133
页数：9
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