Adipose Tissue-Derived Stem Cells: Immunomodulatory Effects and Therapeutic Potential

被引：120

作者：

Al-Ghadban, Sara ^{[1
]}

Bunnell, Bruce A. ^{[1
,2
]}

机构：

[1] Tulane Univ, Sch Med, Ctr Stem Cell Res & Regenerat Med, 1430 Tulane Ave, New Orleans, LA 70112 USA

[2] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA

来源：

PHYSIOLOGY | 2020年 / 35卷 / 02期

关键词：

adipose-derived stem cells; stromal vascular fraction; immune cells; cytokines; mechanisms of action; immunological disease; STROMAL-VASCULAR FRACTION; VERSUS-HOST-DISEASE; REGULATORY T-CELLS; HUMAN BONE-MARROW; EPITHELIAL DIFFERENTIATION; ENDOTHELIAL-CELLS; SUBCUTANEOUS FAT; CARDIAC-FUNCTION; IN-VIVO; EXOSOMES;

D O I：

10.1152/physiol.00021.2019

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Adipose-derived stem cells (ASCs) can self-renew and differentiate along multiple cell lineages. ASCs are also potently anti-inflammatory due to their inherent ability to regulate the immune system by secreting anti-inflammatory cytokines and growth factors that play a crucial role in the pathology of many diseases, including multiple sclerosis, diabetes mellitus, Crohn's, SLE, and graft-versus-host disease. The immunomodulatory effects and mechanisms of action of ASCs on pathological conditions are reviewed here.

引用

页码：125 / 133

页数：9

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