Comparative Efficacy of Multiple Therapies for the Treatment of Patients With Subthreshold Depression: A Systematic Review and Network Meta-Analysis

被引：12

作者：

Jiang, Xiumin ^{[1
]}

Luo, Yongxin ^{[2
]}

Chen, Yiwen ^{[1
]}

Yan, Jinglan ^{[1
]}

Xia, Yucen ^{[1
]}

Yao, Lin ^{[3
]}

Wang, Xiaotong ^{[1
]}

He, Su ^{[1
]}

Wang, Feixue ^{[3
]}

Wang, Taiyi ^{[3
]}

Chen, Yongjun ^{[1
,3
,4
]}

机构：

[1] Guangzhou Univ Chinese Med, South China Res Ctr Acupuncture & Moxibust, Clin Med Coll Acupuncture Moxibust & Rehabil, Guangzhou, Peoples R China

[2] Guangzhou Univ Chinese Med, Sch Basic Med Sci, Dept Biostat & Prevent Med, Guangzhou, Peoples R China

[3] Shandong Univ Tradit Chinese Med, Res Inst Acupuncture & Moxibust, Jinan, Peoples R China

[4] Guangdong Hong Kong Macao Greater Bay Area Ctr Br, Guangzhou, Peoples R China

来源：

FRONTIERS IN BEHAVIORAL NEUROSCIENCE | 2021年 / 15卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

subthreshold depression; multiple therapies; network meta-analysis; systematic review; Bayesian analysis; SEASONAL AFFECTIVE-DISORDER; MINOR DEPRESSION; SUBSYNDROMAL DEPRESSION; BEHAVIORAL ACTIVATION; LIGHT THERAPY; PRIMARY-CARE; DSM-IV; HEALTH; NEUROINFLAMMATION; INTERVENTION;

D O I：

10.3389/fnbeh.2021.755547

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Background: Subthreshold depression (SD) is considered to be the precursor stage of major depression, which is correlated with functional impairment and increased suicide rate. Although there are multiple therapies for the treatment of SD, the comparison and efficacy of various methods has yet to be evaluated. This study aimed to evaluate the efficacy of different therapies by performing a Bayesian network meta-analysis. Methods: We searched eight databases on April 3, 2021. Center for Epidemiologic Studies Depression Scale (CES-D), Beck Depression Inventory scale (BDI), the Patient Health Questionnaire-9 (PHQ-9), and the Kessler Screening Scale for Psychological Distress (K-6) were used as efficacy outcomes. This Bayesian network meta-analysis used a fixed-effects model. Findings: Twenty-one randomized controlled trials involving 5,048 participants were included in this study. The results suggested that electroacupuncture (MD -12.00, 95% CrI -15.00, -10.00), conventional acupuncture plus wheat-grain moxibustion (MD -9.70, 95% CrI -14.00, -5.30), and the Chinese traditional peripateticism pill plus group counseling (MD -9.00, 95% CrI -11.00, -6.70) had better efficacy than the control group (CG) in improving CES-D. For BDI outcome, bright light therapy (MD -9.70, 95% CrI -13.00, -6.00), behavioral activation program (MD -5.70, 95% CrI -6.10, -5.40), and dim light therapy (MD -6.30, 95% CrI -10.00, -2.20) were better than the CG. Tai chi (MD -3.00, 95% CrI -4.00, -2.00) was better than CG for PHQ-9 outcomes. Telephone-based cognitive behavioral treatment (MD -2.50 95% CrI -2.70, -2.30) was better than the CG for K-6 scores. Conclusion: Our results suggest that electroacupuncture or bright light therapy appear to be the better choices in the treatment of SD. This study provide new insights into clinical treatment selection and may aid the development of guidelines for the management of SD.

引用

页数：11

共 79 条

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