Cobalt-catalyzed coupling reactions of 2-halobenzamides with alkynes: investigation of ligand-controlled dual pathways

被引：13

作者：

Thorat, Vijaykumar H. ^{[1
]}

Aman, Hasil ^{[2
]}

Tsai, Yu-Lin ^{[1
]}

Pallikonda, Gangaram ^{[1
]}

Chuang, Gary Jing ^{[2
]}

Hsieh, Jen-Chieh ^{[1
]}

机构：

[1] Tamkang Univ, Dept Chem, New Taipei 251301, Taiwan

[2] Chung Yuan Christian Univ, Dept Chem, Taoyuan 320314, Taiwan

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 22期

关键词：

C-H ACTIVATION; AROMATIC AMIDES; OXIDATIVE ANNULATION; ASYMMETRIC CYCLOPROPANATION; N-ALKYL; BENZAMIDES; ISOQUINOLONES; HALIDES; ROUTE; FUNCTIONALIZATION;

D O I：

10.1039/d1qo01402a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Co-catalyzed reactions of 2-halobenzamides and alkynes to form isoquinolones or 2-vinyl benzamides are described here. The formation of the two selective products can be fully controlled by adopted ligands. A study of the mechanism demonstrated that these two reactions proceed through different pathways. The radical process and the two-electron transfer activation of the C-X bond are respectively proposed for these two reactions.

引用

页码：6419 / 6426

页数：8

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