Microwave-Assisted Aminocarbonylation of Ynamides by Using Catalytic [Fe3(CO)12] at Low Pressures of Carbon Monoxide

被引：37

作者：

Pizzetti, Marianna ^{[1
]}

Russo, Adele ^{[1
]}

Petricci, Elena ^{[1
]}

机构：

[1] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 16期

关键词：

acrylamides; carbon monoxide; carbonylation; iron; microwave chemistry; ynamides; C-H ACTIVATION; ASTERISK-CARBONYLIERUNG; EFFICIENT SYNTHESIS; ARYL HALIDES; CARBONYLATION REACTIONS; COUPLING REACTIONS; ORGANIC-SYNTHESIS; TERMINAL ALKYNES; VERSATILE TOOLS; METAL CATALYSIS;

D O I：

10.1002/chem.201100447

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The microwave-assisted aminocarbonylation of ynamides at low pressures of CO is reported. A new class of (E)-acrylamides that are potentially suitable for several applications has been regioselectively synthesized after microwave irradiation for only 20 min by using eco-friendly [Fe-3(CO)(12)] as the catalyst precursor and triethylamine as the ligand. This transformation is atom economic as all reactants are used in stoichiometric quantities. Furthermore, the transformation is efficiently applied to the alkoxycarbonylation of alkynes as well. Moreover, running these reactions under microwave irradiation allows the simplification of the reaction conditions with remarkable reductions in time, temperature and gas pressure.

引用

页码：4523 / 4528

页数：6

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