Application of lipidomics to reveal differences in facial skin surface lipids between males and females

被引：31

作者：

Cui, Le ^{[1
,2
]}

He, Cong-fen ^{[1
,2
]}

Fan, Lin-na ^{[1
,2
]}

Jia, Yan ^{[1
,2
]}

机构：

[1] Beijing Technol & Business Univ, Sch Sci, Beijing Key Lab Plant Resources Res & Dev, Beijing, Peoples R China

[2] Beijing Technol & Business Univ, Sch Sci, Key Lab Cosmet China Natl Light Ind, Beijing, Peoples R China

来源：

JOURNAL OF COSMETIC DERMATOLOGY | 2018年 / 17卷 / 06期

基金：

中国国家自然科学基金;

关键词：

facial skin surface lipids; males and females; OPLS-DA; UPLC-Q-TOF-MS; APOPTOSIS; CELLS;

D O I：

10.1111/jocd.12474

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Purpose To analyze and compare differences in facial skin surface lipids (SSL) between 18- to 25-year-old males and females. Methods Ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS) technology was used to measure the facial SSL composition of 18- to 25-year-old males and females. Measurement results were combined with the orthogonal projections to latent structures discriminant analysis (OPLS-DA) model for analysis and comparisons, and differences in lipids with significance were selected. Results There were significant differences in facial SSL composition between 18- to 25-year-old males and females. Under selected conditions, 37 types of lipids with significant differences were obtained (P <= .05). All of them had higher content in females, and primarily included ceramides (Cers), glucosylceramide (GlcCer), phosphatidylserine (PS), phosphatidylcholine (PC), and others. Conclusions There are significant differences in facial SSL between 18- to 25-year-old males and females.

引用

页码：1254 / 1261

页数：8

共 16 条

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Bi Yong-xian, 2012, Detergent & Cosmetics, V35, P42

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