Advances in the synthesis of α-quaternary α-ethynyl α-amino acids

被引：18
作者：
Boibessot, Thibaut [1 ]
Benimelis, David [1 ]
Meffre, Patrick [1 ]
Benfodda, Zohra [1 ]
机构：
[1] Univ Nimes, EA7352, CHROME, Rue Dr G Salan, F-30021 Nimes 1, France
来源：
AMINO ACIDS | 2016年 / 48卷 / 09期
关键词：
alpha-Quaternary alpha-ethynyl alpha-amino acids; Quaternary amino acid; Unsaturated amino acid; STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; ENZYME INACTIVATORS; PART; DERIVATIVES; ANALOGS; ESTERS; METATHESIS; EFFICIENT;
D O I：
10.1007/s00726-016-2276-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
alpha-Quaternary alpha-ethynyl alpha-amino acids are an important class of non-proteinogenic amino acids that play an important role in the development of peptides and peptidomimetics as therapeutic agents and in the inhibition of enzyme activities. This review provides an overview of the literature concerning synthesis and applications of alpha-quaternary alpha-ethynyl alpha-amino acids covering the period from 1977 to 2015.
引用
收藏
页码：2081 / 2101
页数：21
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