Synthesis, characterization, and in vitro evaluation of a potentially selective anticancer, mixed-metal [ruthenium(III)-platinum(II)] trinuclear complex

被引：45
作者：
Herman, Amnon [1 ]
Tanski, Joseph M. [2 ]
Tibbetts, Michael F. [1 ]
Anderson, Craig M. [1 ]
机构：
[1] Bard Coll, Dept Chem, New York, NY 12504 USA
[2] Vassar Coll, New York, NY 12604 USA
来源：
INORGANIC CHEMISTRY | 2008年 / 47卷 / 01期
关键词：
D O I：
10.1021/ic062419h
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new type of mixed-metal trinuclear complex containing platinum(II) and ruthenium(III) fragments that resemble both cisplatin and NAMI-A has been synthesized and characterized by IR, H-1 NMR, elemental analysis, and X-ray crystallography. The water-soluble compound Na-2{trans,cis,trans-[(RuCl4)-Cl-III(DMSO-S)(mu-pyz)](2)(PtCl2)-Cl-II} (AH-197, pyz = pyrazine) was assessed for its effects on DNA mobility and toxicity against human cancer cell lines. When compared to cisplatin and KP-1019 (which structurally resembles NAMI-A), IC50 results showed that AH-197 had an intermediate toxicity. When this data was coupled with a subsequent COMPARE evaluation (standard COMPARE queries resulted in insignificant correlation coefficients (<0.70) while very low COMPARE correlation coefficients were found in the matrix queries as well), AH-197 yielded a correlation coefficient of 0.19 when compared to cisplatin and 0.25 when compared to KP1019 indicating that AH-197 has a unique behavior.
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页码：274 / 280
页数：7
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