A RAPID AND HIGH-YIELDING SYNTHESIS OF THIAZOLES AND AMINOTHIAZOLES USING TETRABUTYLAMMONIUM SALTS

被引：9

作者：

Kocabas, Erdal ^{[1
]}

Sariguney, Ahmet Burak ^{[1
]}

Coskun, Ahmet ^{[1
]}

机构：

[1] Selcuk Univ, Dept Chem, TR-42099 Konya, Turkey

来源：

HETEROCYCLES | 2010年 / 81卷 / 12期

关键词：

AQUEOUS-PHASE SYNTHESIS; EFFICIENT SYNTHESIS; 2-AMINOTHIAZOLES; DERIVATIVES; INHIBITORS;

D O I：

10.3987/COM-10-12067

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for the synthesis of thiazoles and aminothiazoles by treatment of phenacyl bromides with thioamides/thiourea in the presence of tetra butylammonium hexafluorophosphate (Bu4NPF6) at room temperature was developed. The products having high yields were formed rapidly (within 15 min). The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. The structures of the newly synthesized products were identified by FT-IR, H-1 NMR, C-13 NMR spectroscopy and elemental analysis data.

引用

页码：2849 / 2854

页数：6

共 23 条

[21] SYNTHESIS AND ANTI-PSEUDOMONAL ACTIVITY OF NEW 2-ISOCEPHEMS WITH A DIHYDROXYPYRIDONE MOIETY AT C-7 [J].