Long-Term Clinical and Immunological Impact of Severe COVID-19 on a Living Kidney Transplant Recipient - A Case Report

被引：3

作者：

Qiu, Liru ^{[1
]}

Zhang, Ji ^{[2
,3
,4
,5
,6
]}

Huang, Yafei ^{[7
]}

Chen, Gen ^{[8
]}

Chen, Zhishui ^{[5
,6
]}

Ming, Changsheng ^{[5
,6
]}

Lu, Xia ^{[5
,6
]}

Gong, Nianqiao ^{[5
,6
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pediat, Wuhan, Peoples R China

[2] Anhui Med Univ, Dept Urol, Affiliated Hosp 1, Hefei, Peoples R China

[3] Anhui Med Univ, Inst Urol, Hefei, Peoples R China

[4] Anhui Med Univ, Anhui Prov Key Lab Genitourinary Dis, Hefei, Peoples R China

[5] Huazhong Univ Sci & Technol, Inst Organ Transplantat, Key Lab Organ Transplantat, Tongji Med Coll,Tongji Hosp,Minist Educ,Natl Hlth, Wuhan, Peoples R China

[6] Chinese Acad Med Sci, Wuhan, Peoples R China

[7] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan, Peoples R China

[8] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Radiol, Wuhan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

COVID-19; living kidney transplant; lung injury; renal tubular injury; immunity; CORONAVIRUS DISEASE 2019;

D O I：

10.3389/fimmu.2021.741765

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The long-term impact of COVID-19 on transplant recipients remains unknown. We describe the case of a 30-year-old male kidney transplant recipient from Wuhan, China that was treated for severe COVID-19 in February 2020. He suffered an acute lung and renal injury and required systemic treatment including adjustment of his immunosuppressant regime. He was followed up to 1-year after discharge. No chronic lung fibrosis or deterioration of his pulmonary function was observed. Despite COVID-19 mediated damage to his renal tubular cells, no transplant rejection occurred. His immunological profile demonstrated both cellular anti-SARS-CoV-2 reactivity and specific humoral immunity, indicating that it is beneficial for the transplanted patients to be immunized with SARS-CoV-2 virus vaccine. This case will help guide clinical decision making for immunocompromised individuals that become infected with SARS-CoV-2.

引用

页数：8

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