Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion

被引:419
作者
Kuroda, S
Fukata, M
Nakagawa, M
Fujii, K
Nakamura, T
Ookubo, T
Izawa, I
Nagase, T
Nomura, N
Tani, H
Shoji, I
Matsuura, Y
Yonehara, S
Kaibuchi, K [1 ]
机构
[1] Nara Inst Sci & Technol, Div Signal Transduct, Ikoma 6300101, Japan
[2] Japan Sci & Technol, PRESTO, Inheritance & Variat Grp, Kyoto 6190237, Japan
[3] Hiroshima Univ, Sch Med, Dept Biochem, Hiroshima 7348551, Japan
[4] Cent Lab Key Technol, Kirin Brewery, Yokohama 2360004, Japan
[5] Kazusa DNA Res Inst, Kazusa CDNA Res Grp, Kisarazu 2920812, Japan
[6] Natl Inst Infect Dis, Dept Virol 2, Tokyo 1620052, Japan
[7] Kyoto Univ, Inst Virus Res, Kyoto 6068397, Japan
关键词
D O I
10.1126/science.281.5378.832
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The small guanosine triphosphatases (GTPases) Cdc42 and Rad regulate E-cadherin-mediated cell-cell adhesion. IQGAP1, a target: of Cdc42 and Rac1,was localized with E-cadherin and beta-catenin at sites of cell-cell contact in mouse L Fibroblasts expressing E-cadherin (EL cells), and interacted with E-cadherin and beta-catenin both in vivo and in vitro. IQGAP1 induced the dissociation of alpha-catenin from a cadherin-catenin complex in vitro and in vivo. Overexpression of IQGAP1 in EL cells, but not in L cells expressing an E-cadherin-alpha-catenin chimeric protein, resulted in a decrease in E-cadherin-mediated cell-cell adhesive activity. Thus, IQGAP1, acting downstream of Cdc42 and Rac1, appears to regulate cell-cell adhesion through the cadherin-catenin pathway.
引用
收藏
页码:832 / 835
页数:4
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