Aquaporin-4 and Cerebrovascular Diseases

被引：55
作者：
Chu, Heling [1 ]
Huang, Chuyi [2 ]
Ding, Hongyan [1 ]
Dong, Jing [1 ]
Gao, Zidan [1 ]
Yang, Xiaobo [1 ,3 ]
Tang, Yuping [1 ]
Dong, Qiang [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Neurol, State Key Lab Med Neurobiol, 12 Mid Wulumuqi Rd, Shanghai 200040, Peoples R China
[2] Shanghai Jiao Tong Univ, Dept Neurol, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200030, Peoples R China
[3] Fudan Univ, Jinshan Hosp, Dept Neurol, 1508 Longhang Rd, Shanghai 201508, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 08期
关键词：
aquaporin-4; cerebral ischemia; intracerebral hemorrhage; subarachnoid hemorrhage; BLOOD-BRAIN-BARRIER; FOCAL CEREBRAL-ISCHEMIA; CHANNEL PROTEIN AQUAPORIN-4; WATER CHANNEL; SUBARACHNOID HEMORRHAGE; INTRACEREBRAL HEMORRHAGE; SYNAPTIC PLASTICITY; UP-REGULATION; TIME-COURSE; RAT-BRAIN;
D O I：
10.3390/ijms17081249
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cerebrovascular diseases are conditions caused by problems with brain vasculature, which have a high morbidity and mortality. Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema. Considering brain edema is an important pathophysiological change after stoke, AQP4 is destined to have close relation with cerebrovascular diseases. However, this relation is not limited to brain edema due to other biological effects elicited by AQP4. Till now, multiple studies have investigated roles of AQP4 in cerebrovascular diseases. This review focuses on expression of AQP4 and the effects of AQP4 on brain edema and neural cells injuries in cerebrovascular diseases including cerebral ischemia, intracerebral hemorrhage and subarachnoid hemorrhage. In the current review, we pay more attention to the studies of recent years directly from cerebrovascular diseases animal models or patients, especially those using AQP4 gene knockout mice. This review also elucidates the potential of AQP4as an excellent therapeutic target.
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页数：15
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