Translocation Renal Cell Carcinoma: An Update on Clinicopathological and Molecular Features

被引：50
作者：
Inamura, Kentaro [1 ]
机构：
[1] Japanese Fdn Canc Res, Canc Inst, Div Pathol, Koto Ku, 3-8-31 Ariake, Tokyo 1358550, Japan
来源：
CANCERS | 2017年 / 9卷 / 09期
关键词：
ALK; fusion; kidney; renal cell carcinoma; TFE3; TFEB; translocation; BREAK-APART FISH; GENE FUSION; CATHEPSIN-K; LARGE SERIES; TFE3; IMMUNOREACTIVITY; CRIZOTINIB; NEOPLASMS; T(6/11)(P21; Q12); HETEROGENEITY;
D O I：
10.3390/cancers9090111
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Microphthalmia-associated transcription (MiT) family translocation renal cell carcinoma (tRCC) comprises Xp11 tRCC and t(6;11) RCC. Due to the presence of fusion genes, Xp11 tRCC and t(6;11) RCC are also known as TFE3- and TFEB-rearranged RCC, respectively. TFE3 and TFEB belong to the MiT family, which regulates melanocyte and osteoclast differentiation, and TFE3- and TFEB-rearranged RCC show characteristic clinicopathological and immunohistochemical features. Recent studies identified the fusion partner-dependent clinicopathological and immunohistochemical features in TFE3-rearranged RCC. Furthermore, RCC with chromosome 6p amplification, including TFEB, was identified as a unique subtype of RCC, along with ALK-rearranged RCC. This review summarizes these recent advancements in our tRCC-related knowledge.
引用
收藏
页数：11
相关论文
共 61 条
[1]  
[Anonymous], 2016, WHO classification of tumours of the urinary system and male genital organs
[2]   Renal carcinomas with the t(6;11)(p21;q12) -: Clinicopathologic features and demonstration of the specific Alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR [J].
Argani, P ;
Laé, M ;
Hutchinson, B ;
Reuter, VE ;
Collins, MH ;
Perentesis, J ;
Tomaszewski, JE ;
Brooks, JSJ ;
Acs, G ;
Bridge, JA ;
Vargas, SO ;
Davis, IJ ;
Fisher, DE ;
Ladanyi, M .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2005, 29 (02) :230-240
[3]   Translocation carcinomas of the kidney after chemotherapy in childhood [J].
Argani, P ;
Laé, M ;
Ballard, ET ;
Amin, M ;
Manivel, C ;
Hutchinson, B ;
Reuter, VE ;
Ladanyi, M .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (10) :1529-1534
[4]   PRCC-TFE3 renal carcinomas -: Morphologic, immunohistochemical, ultrastructural, and molecular analysis of an entity associated with the t(X;1)(p11.2;q21) [J].
Argani, P ;
Antonescu, CR ;
Couturier, J ;
Fournet, JC ;
Sciot, R ;
Debiec-Rychter, M ;
Hutchinson, B ;
Reuter, VE ;
Boccon-Gibod, L ;
Timmons, C ;
Hafez, N ;
Ladanyi, M .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2002, 26 (12) :1553-1566
[5]   Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions -: A sensitive and specific immunohistochemical assay [J].
Argani, P ;
Lal, P ;
Hutchinson, B ;
Lui, MY ;
Reuter, VE ;
Ladanyi, M .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2003, 27 (06) :750-761
[6]   Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma -: A distinctive tumor entity previously included among renal cell carcinomas of children and adolescents [J].
Argani, P ;
Antonescu, CR ;
Illei, PB ;
Lui, MY ;
Timmons, CF ;
Newbury, R ;
Reuter, VE ;
Garvin, AJ ;
Perez-Atayde, AR ;
Fletcher, JA ;
Beckwith, JB ;
Bridge, JA ;
Ladanyi, M .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 159 (01) :179-192
[7]   A distinctive pediatric renal neoplasm characterized by epithelioid morphology, basement membrane production, focal HMB45 immunoreactivity, and t(6;11)(p21.1;q12) chromosome translocation [J].
Argani, P ;
Hawkins, A ;
Griffin, CA ;
Goldstein, JD ;
Haas, M ;
Beckwith, JB ;
Mankinen, CB ;
Perlman, EJ .
AMERICAN JOURNAL OF PATHOLOGY, 2001, 158 (06) :2089-2096
[8]   RBM10-TFE3 Renal Cell Carcinoma A Potential Diagnostic Pitfall Due to Cryptic Intrachromosomal Xp11.2 Inversion Resulting in False-negative TFE3 FISH [J].
Argani, Pedram ;
Zhang, Lei ;
Reuter, Victor E. ;
Tickoo, Satish K. ;
Antonescu, Cristina R. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2017, 41 (05) :655-662
[9]   TFEB-amplified Renal Cell Carcinomas An Aggressive Molecular Subset Demonstrating Variable Melanocytic Marker Expression and Morphologic Heterogeneity [J].
Argani, Pedram ;
Reuter, Victor E. ;
Zhang, Lei ;
Sung, Yun-Shao ;
Ning, Yi ;
Epstein, Jonathan I. ;
Netto, George J. ;
Antonescu, Cristina R. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2016, 40 (11) :1484-1495
[10]  
Argani P, 2016, AM J SURG PATHOL, V40, P723, DOI 10.1097/PAS.0000000000000631
1234567