CAG repeat polymorphism in the androgen receptor: a study on the effect of different numbers of repeats using Gene Ontology technique

Objective: To study the effect of different numbers of repeats of the AR. Design: Experimental study. Setting: A university in Thailand. Patient(s): Nucleic acid sequences of the general male population. Intervention(s): A new Gene Ontology technology to predict the aberration of the molecular function of the AR as a result of different numbers of repeats of CAG. Main Outcome Measure(s): Molecular function. Result(s): Repeats of CAG up to 127 times cause no effect on expression of AR in molecular function. Indeed, there have been limited reports on the number of repeats and correlation to clinical phenotypes. Conclusion(s): The number of repeats is very high, and there has been no prior report indicating as many repeats as we found. Therefore, the CAG repeat polymorphism in AR appears to be a nonsignificant polymorphism in affecting gross phenotype. (Fertil Steril (R) 2009; 91:e5-e6. (C) 2009 by American Society for Reproductive Medicine.)