Synthesis of [4-(2-Hydroxyphenyl)thiazol-2-yl]methanones as Potential Bioisosteres of Salicylidene Acylhydrazides

被引：5
作者：
Hillgren, J. Mikael [1 ]
Dahlgren, Markus K. [1 ]
To, Tam M. [1 ]
Elofsson, Mikael [1 ]
机构：
[1] Umea Univ, Dept Chem, SE-90187 Umea, Sweden
来源：
MOLECULES | 2010年 / 15卷 / 09期
基金：
瑞典研究理事会;
关键词：
type III secretion; Suzuki coupling; Grignard addition; SMALL-MOLECULE INHIBITORS; ENTERICA SEROVAR TYPHIMURIUM; III SECRETION INHIBITORS; CHLAMYDIA-TRACHOMATIS; PROTEIN SECRETION; IDENTIFICATION; VIRULENCE; YERSINIA; CYCLE; BACTERIA;
D O I：
10.3390/molecules15096019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A focused library of [4-(2-hydroxyphenyl)thiazol-2-yl]methanones was prepared in a four-step synthesis with the aim to obtain potent inhibitors of type III secretion in Gram-negative bacteria. The compounds are potential bioisosteres of salicylidene acylhydrazides that are a known class of type III secretion inhibitors.
引用
收藏
页码：6019 / 6034
页数：16
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