Asymmetric Synthesis of (-)-1-hydroxyquinolizidinone, a common intermediate for the syntheses of (-)-homopumiliotoxin 223G and (-)-epiquinamide

被引：52

作者：

Voituriez, Arnaud ^{[1
]}

Ferreira, Franck ^{[1
]}

Perez-Luna, Alejandro ^{[1
]}

Chemla, Fabrice ^{[1
]}

机构：

[1] Univ Paris 06, Chim Organ Lab, CNRS, UMR 7611,Inst Chim Mol,FR 2769, F-75252 Paris 05, France

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 23期

关键词：

D O I：

10.1021/ol701952y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The short and efficient asymmetric synthesis of (-)-1-hydroxyquinolizidinone was achieved in seven steps and 25.2% overall yield from readily available 5-chloropentanal. It is a key intermediate in the formal syntheses of (-)-homopumilotoxin 223G and (-)-epiquinamide.

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收藏

页码：4705 / 4708

页数：4

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