Organocatalytic Site-Selective Acylation of 10-Deacetylbaccatin III

被引：16

作者：

Yanagi, Masanori ^{[1
]}

Ninomiya, Ryo ^{[1
]}

Ueda, Yoshihiro ^{[1
]}

Furuta, Takumi ^{[1
]}

Yamada, Takeshi ^{[2
,3
]}

Sunazuka, Toshiaki ^{[2
,3
]}

Kawabata, Takeo ^{[1
]}

机构：

[1] Kyoto Univ, Inst Chem Res, Uji, Kyoto 6110011, Japan

[2] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, 5-9-1 Shirokane, Tokyo 1088641, Japan

[3] Kitasato Univ, Grad Sch Infect Control Sci, Minato Ku, 5-9-1 Shirokane, Tokyo 1088641, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2016年 / 64卷 / 07期

关键词：

organocatalyst; site-selectivity; acylation; taxane; 10-deacetylbaccatin III; site-selective dimerization; REGIOSELECTIVE ACYLATION; ENZYMATIC ACYLATION; CARDIAC GLYCOSIDE; VANCOMYCIN DIMERS; TAXOL; CHEMISTRY; BACCATIN;

D O I：

10.1248/cpb.c16-00037

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Organocatalytic site-selective diversification of 10-deacetylbaccatin III, a key natural product for the semisynthesis of taxol, has been achieved. Various acyl groups were selectively introduced into the C(10)-OH of 10-deacetylbaccatin III. The C(10)-OH selective acylation was also applied to acylative site-selective dimerization of 10-deacetylbaccatin III to provide the structurally defined dimer.

引用

页码：907 / 912

页数：6

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