Anti protein A antibody-gold nanorods conjugate: a targeting agent for selective killing of methicillin resistant Staphylococcus aureus using photothermal therapy method
被引:24
作者:
Shokri, Rasoul
论文数: 0引用数: 0
h-index: 0
机构:
Islamic Azad Univ, Dept Microbiol, Sci & Res Branch, Fars, IranIslamic Azad Univ, Dept Microbiol, Sci & Res Branch, Fars, Iran
Shokri, Rasoul
[1
]
Salouti, Mojtaba
论文数: 0引用数: 0
h-index: 0
机构:
Islamic Azad Univ, Biol Res Ctr, Zanjan Branch, Zanjan, IranIslamic Azad Univ, Dept Microbiol, Sci & Res Branch, Fars, Iran
Salouti, Mojtaba
[2
]
Zanjani, Rahim Sorouri
论文数: 0引用数: 0
h-index: 0
机构:
Zanjan Univ Med Sci, Zanjan, IranIslamic Azad Univ, Dept Microbiol, Sci & Res Branch, Fars, Iran
Zanjani, Rahim Sorouri
[3
]
机构:
[1] Islamic Azad Univ, Dept Microbiol, Sci & Res Branch, Fars, Iran
[2] Islamic Azad Univ, Biol Res Ctr, Zanjan Branch, Zanjan, Iran
Methicillin Resistant Staphylococcus aureus;
photothermal therapy;
gold nanorods;
anti protein A antibody;
NANOPARTICLES;
BACTERIA;
D O I:
10.1007/s12275-015-4519-4
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The high prevalence of methicillin resistant Staphylococcus aureus (MRSA) and developing resistance to antibiotics requires new approaches for treatment of infectious diseases due to this bacterium. In this study, we developed a targeting agent for selective killing of MRSA using photothermal therapy method based on anti protein A antibody and gold nanorods (GNRs). Polystyrene sulfonate (PSS) coated GNRs were conjugated with anti protein A antibody. The FT-IR and UV-vis analyses approved the formation of anti protein A antibody-gold nanorods conjugate. In vitro study of photothermal therapy showed 82% reduction in the MRSA cells viability which was significantly greater than the ablation effect of free GNRs and laser alone. Significant accumulation of anti protein A antibody-GNRs in the infected muscle in comparison with normal muscle approved the targeting ability of new agent. In vivo study of photothermal therapy resulted in a significant reduction (73%) in the bacterial cells viability in the infected mouse model. These results demonstrated the ability of anti protein A antibody-GNRs conjugate in combination with NIR laser energy for selective killing of MRSA in mouse model.
机构:
Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
El-Sayed, Ivan H.
;
Huang, Xiaohua
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
Huang, Xiaohua
;
El-Sayed, Mostafa A.
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Fernandes, Sofia
;
Proenca, Daniela
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Proenca, Daniela
;
Cantante, Catia
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Cantante, Catia
;
Silva, Filipa Antunes
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Silva, Filipa Antunes
;
Leandro, Clara
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Leandro, Clara
;
Lourenco, Sara
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Lourenco, Sara
;
Milheirico, Catarina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, Inst Tecnol Quim & Biol, Mol Genet Lab, P-2780156 Oeiras, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Milheirico, Catarina
;
de Lencastre, Herminia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, Inst Tecnol Quim & Biol, Mol Genet Lab, P-2780156 Oeiras, Portugal
Rockefeller Univ, Microbiol Lab, New York, NY 10021 USAUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
de Lencastre, Herminia
;
Cavaco-Silva, Patricia
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, Portugal
Ctr Interdisciplinary Res Egas Moniz, Monte De Caparica, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Cavaco-Silva, Patricia
;
Pimentel, Madalena
论文数: 0引用数: 0
h-index: 0
机构:Univ Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Pimentel, Madalena
;
Sao-Jose, Carlos
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Inst Mol Med, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
机构:
Univ Arkansas Med Sci, Phillips Class Laser & Nanomed Labs, Little Rock, AR 72205 USA
Univ Arkansas Med Sci, Arkansas Nanomed Ctr, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Galanzha, Ekaterina I.
;
Shashkov, Evgeny
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas Med Sci, Phillips Class Laser & Nanomed Labs, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Shashkov, Evgeny
;
论文数: 引用数:
h-index:
机构:
Sarimollaoglu, Mustafa
;
Beenken, Karen E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Beenken, Karen E.
;
Basnakian, Alexei G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Basnakian, Alexei G.
;
Shirtliff, Mark E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maryland Baltimore, Sch Dent, Dept Mol Pathogenesis, Baltimore, MD USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Shirtliff, Mark E.
;
Kim, Jin-Woo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas, Inst Nanosci & Engn, Bio Nano Technol Lab, Fayetteville, AR 72701 USA
Univ Arkansas, Dept Biol & Agr Engn, Fayetteville, AR 72701 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Kim, Jin-Woo
;
Smeltzer, Mark S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Smeltzer, Mark S.
;
Zharov, Vladimir P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas Med Sci, Phillips Class Laser & Nanomed Labs, Little Rock, AR 72205 USA
Univ Arkansas Med Sci, Arkansas Nanomed Ctr, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
机构:
Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USAUniv Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
El-Sayed, Ivan H.
;
Huang, Xiaohua
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
Huang, Xiaohua
;
El-Sayed, Mostafa A.
论文数: 0引用数: 0
h-index: 0
机构:Univ Calif San Francisco, Ctr Comprehens Canc, Otolaryngol Head & Neck Surg, San Francisco, CA 94143 USA
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Fernandes, Sofia
;
Proenca, Daniela
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Proenca, Daniela
;
Cantante, Catia
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Cantante, Catia
;
Silva, Filipa Antunes
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Silva, Filipa Antunes
;
Leandro, Clara
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Leandro, Clara
;
Lourenco, Sara
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Lourenco, Sara
;
Milheirico, Catarina
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, Inst Tecnol Quim & Biol, Mol Genet Lab, P-2780156 Oeiras, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Milheirico, Catarina
;
de Lencastre, Herminia
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, Inst Tecnol Quim & Biol, Mol Genet Lab, P-2780156 Oeiras, Portugal
Rockefeller Univ, Microbiol Lab, New York, NY 10021 USAUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
de Lencastre, Herminia
;
Cavaco-Silva, Patricia
论文数: 0引用数: 0
h-index: 0
机构:
Technophage SA, Lisbon, Portugal
Ctr Interdisciplinary Res Egas Moniz, Monte De Caparica, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Cavaco-Silva, Patricia
;
Pimentel, Madalena
论文数: 0引用数: 0
h-index: 0
机构:Univ Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Pimentel, Madalena
;
Sao-Jose, Carlos
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
Inst Mol Med, Lisbon, PortugalUniv Lisbon, Fac Farm, Dept Microbiol & Imunol, CPM,URIA, P-1649003 Lisbon, Portugal
机构:
Univ Arkansas Med Sci, Phillips Class Laser & Nanomed Labs, Little Rock, AR 72205 USA
Univ Arkansas Med Sci, Arkansas Nanomed Ctr, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Galanzha, Ekaterina I.
;
Shashkov, Evgeny
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas Med Sci, Phillips Class Laser & Nanomed Labs, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Shashkov, Evgeny
;
论文数: 引用数:
h-index:
机构:
Sarimollaoglu, Mustafa
;
Beenken, Karen E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Beenken, Karen E.
;
Basnakian, Alexei G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Basnakian, Alexei G.
;
Shirtliff, Mark E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maryland Baltimore, Sch Dent, Dept Mol Pathogenesis, Baltimore, MD USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Shirtliff, Mark E.
;
Kim, Jin-Woo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas, Inst Nanosci & Engn, Bio Nano Technol Lab, Fayetteville, AR 72701 USA
Univ Arkansas, Dept Biol & Agr Engn, Fayetteville, AR 72701 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Kim, Jin-Woo
;
Smeltzer, Mark S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA
Smeltzer, Mark S.
;
Zharov, Vladimir P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas Med Sci, Phillips Class Laser & Nanomed Labs, Little Rock, AR 72205 USA
Univ Arkansas Med Sci, Arkansas Nanomed Ctr, Little Rock, AR 72205 USAUniv Arkansas Med Sci, Dept Microbiol & Immunol, Little Rock, AR 72205 USA