Asymmetric Synthesis of Sphinganine and Clavaminol H

被引：40
作者：
Ait-Youcef, Ramzi [1 ]
Moreau, Xavier [1 ]
Greck, Christine [1 ]
机构：
[1] Univ Versailles St Quentin en Yvelines, CNRS, UMR 8180, Inst Lavoisier Versailles, F-78035 Versailles, France
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 15期
关键词：
PROTEIN-KINASE-C; STEREOSELECTIVE-SYNTHESIS; AMINO-ALCOHOLS; SPHINGOLIPIDS; SPHINGOSINE; EFFICIENT; CHEMISTRY;
D O I：
10.1021/jo1003899
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient enantioselective synthesis of sphinganine and clavaminol H is reported. These sphingoid-type bases were obtained from commercially available fatty acids using highly enantioselective Ru-catalyzed hydrogenation and organocatalytic electrophilic amination reactions to create the stereogenic centers.
引用
收藏
页码：5312 / 5315
页数：4
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