Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India

被引：35

作者：

Uthra, Satagopan

Raman, Rajiv

Mukesh, Bickol N.

Kumari, Padmaja

Paul, Pradeep G.

Lakshmipathy, Praveena

Gnanamoorthy, Perumal

Sharma, Tarun

McCarty, Catherine A.

Kumaramanickavel, Govindasamy

机构：

[1] Vis Res Fdn, SN ONGC Dept Genet & Mol Biol, Madras 600006, Tamil Nadu, India

[2] Shri Baghawan Mahavir Vitreoretinal Serv, Madras, Tamil Nadu, India

[3] Med & Vis Res Fdn, Sankara Nethralaya Diabet Retinopathy Project, Madras, Tamil Nadu, India

[4] Marshfield Clin Fdn Med Res & Educ, Marshfield, WI 54449 USA

来源：

OPHTHALMIC GENETICS | 2007年 / 28卷 / 02期

关键词：

diabetic retinopathy; hypoxia; eNOS; intronic VNTR; type; 2; diabetes;

D O I：

10.1080/13816810701209669

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A 27-bp variable number tandem repeat (VNTR) in intron 4 of endothelial nitric oxide synthase (eNOS) gene has been associated with the risk for developing diabetic retinopathy (DR) in various ethnic populations. Hundred and eighty seven patients with retinopathy (cases; DR+) and 188 patients without retinopathy (controls: DR-) from southern India who had type 2 diabetes mellitus (T2DM) for more than 10 years, were included in the study. We could neither find significant allelic association with clinical severity of DR nor with macular edema. Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India.

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收藏

页码：77 / 81

页数：5

相关论文

共 26 条

[1] Sankara Nethralaya-Diabetic Retinopathy Epidemiolopy and Molecular Genetic Study (SN-DREAMS 1): Study design and research methodology [J].

Agarwal, S ;

Raman, R ;

Paul, PG ;

Rani, PK ;

Uthra, S ;

Gayathree, R ;

McCarty, C ;

Kumaramanickavel, G ;

Sharma, T .

OPHTHALMIC EPIDEMIOLOGY, 2005, 12 (02) :143-153

[2] Protective role of endothelial nitric oxide synthase [J].

Albrecht, EWJA ;

Stegeman, CA ;

Heeringa, P ;

Henning, RH ;

van Goor, H .

JOURNAL OF PATHOLOGY, 2003, 199 (01) :8-17

[3]

[Anonymous], 1996, BRIT MED J, V313, P1448

[4] Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes [J].

Awata, T ;

Neda, T ;

Iizuka, H ;

Kurihara, S ;

Ohkubo, T ;

Takata, N ;

Osaki, M ;

Watanabe, M ;

Nakashima, Y ;

Sawa, T ;

Inukai, K ;

Inoue, I ;

Shibuya, M ;

Mori, K ;

Yoneya, S ;

Katayama, S .

DIABETES CARE, 2004, 27 (09) :2184-2190

[5] NITRIC-OXIDE - A PHYSIOLOGICAL MESSENGER MOLECULE [J].

BREDT, DS ;

SNYDER, SH .

ANNUAL REVIEW OF BIOCHEMISTRY, 1994, 63 :175-195

[6] Endothelial nitric oxide synthase genotype and haplotype are not associated with diabetic retinopathy in diabetes type 2 patients [J].

de Syllos, Roger W. C. ;

Sandrim, Valeria C. ;

Lisboa, Hugo R. K. ;

Tres, Glaucia S. ;

Tanus-Santos, Jose E. .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2006, 15 (04) :417-422

[7] Endothelial nitric oxide synthase (ecNOS) 4 a/b gene polymorphism and carotid artery intima-media thickness in type-1 diabetic patients [J].

Frost, D ;

Chitu, J ;

Meyer, M ;

Beischer, W ;

Pfohl, M .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2003, 111 (01) :12-15

[8] Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability [J].

Fukumura, D ;

Gohongi, T ;

Kadambi, A ;

Izumi, Y ;

Ang, J ;

Yun, CO ;

Buerk, DG ;

Huang, PL ;

Jain, RK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) :2604-2609

[9]

Hattenbach LO, 2000, INVEST OPHTH VIS SCI, V41, P213

[10] Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo [J].

Joussen, AM ;

Poulaki, V ;

Qin, WY ;

Kirchhof, B ;

Mitsiades, N ;

Wiegand, SJ ;

Rudge, J ;

Yancopoulos, GD ;

Adamis, AP .

AMERICAN JOURNAL OF PATHOLOGY, 2002, 160 (02) :501-509